U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    epn1a epsin 1a [ Danio rerio (zebrafish) ]

    Gene ID: 406671, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    epn1aprovided by ZNC
    Official Full Name
    epsin 1aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040426-2680
    See related
    Ensembl:ENSDARG00000010411 AllianceGenome:ZFIN:ZDB-GENE-040426-2680
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    epn1; fd51f09; zgc:56381; wu:fd51f09; wu:fj90e03
    Summary
    Predicted to enable clathrin binding activity and phospholipid binding activity. Predicted to be involved in endocytosis. Predicted to be located in cytoplasm. Predicted to be part of clathrin vesicle coat. Predicted to be active in endosome and plasma membrane. Orthologous to human EPN1 (epsin 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See epn1a in Genome Data Viewer
    Location:
    chromosome: 16
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 16 NC_007127.7 (12730311..12756528)
    105 previous assembly GRCz10 (GCF_000002035.5) 16 NC_007127.6 (12840191..12866408)

    Chromosome 16 - NC_007127.7Genomic Context describing neighboring genes Neighboring gene microfibril associated protein 5 Neighboring gene SH3 domain binding kinase family, member 3 Neighboring gene forkhead box J2 Neighboring gene isochorismatase domain containing 2

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. DNA methylation and gene expression alterations in zebrafish early-life stages exposed to the antibacterial agent triclosan. Falisse E, et al. Environ Pollut, 2018 Dec. PMID 30408875
    2. Loss of gata1 but not gata2 converts erythropoiesis to myelopoiesis in zebrafish embryos. Galloway JL, et al. Dev Cell, 2005 Jan. PMID 15621534
    3. Hematopoietic gene expression profile in zebrafish kidney marrow. Song HD, et al. Proc Natl Acad Sci U S A, 2004 Nov 16. PMID 15520368, Free PMC Article
    4. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

    Go to the top of the page

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables clathrin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables lipid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phospholipid binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in endocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of clathrin vesicle coat IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    epsin-1
    Names
    epsin 1

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001328116.1 → NP_001315045.1  epsin-1

      Status: VALIDATED

      Source sequence(s)
      CR848818, EH439306, EH555046
      UniProtKB/TrEMBL
      A0A0R4IUB6, A0A8M1P8T3, F1Q5Z9
      Related
      ENSDARP00000138794.2, ENSDART00000162030.2
      Conserved Domains (4) summary
      smart00726
      Location:190 → 208
      UIM; Ubiquitin-interacting motif
      cd03571
      Location:19 → 141
      ENTH_epsin; ENTH domain, Epsin family; The epsin (Eps15 interactor) N-terminal homology (ENTH) domain is an evolutionarily conserved protein module found primarily in proteins that participate in clathrin-mediated endocytosis. A set of proteins previously designated ...
      pfam05104
      Location:233 → 371
      Rib_recp_KP_reg; Ribosome receptor lysine/proline rich region
      cl00427
      Location:317 → 371
      TM_PBP2; Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and ...

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007127.7 Reference GRCz11 Primary Assembly

      Range
      12730311..12756528
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_068213932.1 → XP_068070033.1  epsin-1 isoform X5

      UniProtKB/TrEMBL
      A0A8M2B4R0, F1Q5Z9

    2. XM_068213929.1 → XP_068070030.1  epsin-1 isoform X3

      UniProtKB/TrEMBL
      F1Q5Z9

    3. XM_068213931.1 → XP_068070032.1  epsin-1 isoform X4

      UniProtKB/TrEMBL
      F1Q5Z9

    4. XM_068213935.1 → XP_068070036.1  epsin-1 isoform X7

      UniProtKB/TrEMBL
      F1Q5Z9

    5. XM_009292094.4 → XP_009290369.1  epsin-1 isoform X1

      UniProtKB/TrEMBL
      A0A8M3AIX1, F1Q5Z9
      Conserved Domains (4) summary
      smart00726
      Location:190 → 208
      UIM; Ubiquitin-interacting motif
      cd03571
      Location:19 → 141
      ENTH_epsin; ENTH domain, Epsin family; The epsin (Eps15 interactor) N-terminal homology (ENTH) domain is an evolutionarily conserved protein module found primarily in proteins that participate in clathrin-mediated endocytosis. A set of proteins previously designated ...
      pfam05104
      Location:233 → 371
      Rib_recp_KP_reg; Ribosome receptor lysine/proline rich region
      cl00427
      Location:317 → 371
      TM_PBP2; Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and ...

    6. XM_009292096.4 → XP_009290371.1  epsin-1 isoform X9

      UniProtKB/TrEMBL
      A0A8M3AT63, F1Q5Z9
      Conserved Domains (3) summary
      smart00726
      Location:190 → 208
      UIM; Ubiquitin-interacting motif
      cd03571
      Location:19 → 141
      ENTH_epsin; ENTH domain, Epsin family; The epsin (Eps15 interactor) N-terminal homology (ENTH) domain is an evolutionarily conserved protein module found primarily in proteins that participate in clathrin-mediated endocytosis. A set of proteins previously designated ...
      pfam08430
      Location:457 → 564
      Forkhead_N; Forkhead N-terminal region

    7. XM_068213928.1 → XP_068070029.1  epsin-1 isoform X2

      UniProtKB/TrEMBL
      F1Q5Z9

    8. XM_005157886.5 → XP_005157943.1  epsin-1 isoform X5

      UniProtKB/TrEMBL
      A0A8M2B4R0, F1Q5Z9
      Conserved Domains (5) summary
      smart00726
      Location:190 → 209
      UIM; Ubiquitin-interacting motif
      cd03571
      Location:19 → 141
      ENTH_epsin; ENTH domain, Epsin family; The epsin (Eps15 interactor) N-terminal homology (ENTH) domain is an evolutionarily conserved protein module found primarily in proteins that participate in clathrin-mediated endocytosis. A set of proteins previously designated ...
      pfam04871
      Location:191 → 242
      Uso1_p115_C; Uso1 / p115 like vesicle tethering protein, C terminal region
      pfam05104
      Location:200 → 340
      Rib_recp_KP_reg; Ribosome receptor lysine/proline rich region
      cl00427
      Location:286 → 340
      TM_PBP2; Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and ...

    9. XM_068213933.1 → XP_068070034.1  epsin-1 isoform X6

      UniProtKB/TrEMBL
      F1Q5Z9

    10. XM_068213930.1 → XP_068070031.1  epsin-1 isoform X4

      UniProtKB/TrEMBL
      F1Q5Z9

    11. XM_068213934.1 → XP_068070035.1  epsin-1 isoform X7

      UniProtKB/TrEMBL
      F1Q5Z9

    12. XM_068213936.1 → XP_068070037.1  epsin-1 isoform X8

      UniProtKB/TrEMBL
      F1Q5Z9

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_213362.1: Suppressed sequence

      Description
      NM_213362.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Tools