cap1 CAP, adenylate cyclase-associated protein 1 (yeast) [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: cap1provided by ZNC
Official Full Name: CAP, adenylate cyclase-associated protein 1 (yeast)provided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-6459
See related: Ensembl:ENSDARG00000016350 AllianceGenome:ZFIN:ZDB-GENE-030131-6459
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: fj98f01; zgc:63872; wu:fj98f01
Summary: Predicted to enable actin monomer binding activity and adenylate cyclase binding activity. Acts upstream of or within mesodermal cell migration and somitogenesis. Predicted to be located in plasma membrane. Predicted to be active in cytoplasm. Is expressed in ectoderm; embryonic structure; heart; segmental plate; and skeletal muscle. Orthologous to human CAP1 (cyclase associated actin cytoskeleton regulatory protein 1). [provided by Alliance of Genome Resources, Dec 2024]
Annotation information: Annotation category: partial on reference assembly
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 19

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	19	NC_007130.7 (43716001..43737071)
105	previous assembly	GRCz10 (GCF_000002035.5)	19	NC_007130.6 (44120404..44141474)

Chromosome 19 - NC_007130.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The requirement of Cap1 for a cellular apical constriction step suggests a conservation of gene function for a cell biological event critical to many developmental processes.
Title: Control of morphogenetic cell movements in the early zebrafish myotome.
cap1 regulates cortical actin distribution specifically in the anterior mesendoderm of the zebrafish gastrula.
Title: Developmentally restricted actin-regulatory molecules control morphogenetic cell movements in the zebrafish gastrula.

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables actin binding	IBA Inferred from Biological aspect of Ancestor more info
enables actin binding	IEA Inferred from Electronic Annotation more info
enables actin monomer binding	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables adenylate cyclase binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in actin filament organization	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within activation of adenylate cyclase activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in cAMP-mediated signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell morphogenesis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cytoskeleton organization	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within mesodermal cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within somitogenesis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: adenylyl cyclase-associated protein 1

Names: Cap1 CAP, adenylate cyclase-associated protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_199909.2 → NP_956203.1 adenylyl cyclase-associated protein 1

See identical proteins and their annotated locations for NP_956203.1

Status: PROVISIONAL

Source sequence(s)

AY162326

UniProtKB/TrEMBL

A0A8N7UZX2, Q6YBS2

Related

ENSDARP00000020578.7, ENSDART00000006344.9

Conserved Domains (3) summary

smart00673
Location:382 → 419

CARP; Domain in CAPs (cyclase-associated proteins) and X-linked retinitis pigmentosa 2 gene product

pfam01213
Location:5 → 285

CAP_N; Adenylate cyclase associated (CAP) N terminal

pfam08603
Location:312 → 461

CAP_C; Adenylate cyclase associated (CAP) C terminal