mhc1zba major histocompatibility complex class I ZBA [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: mhc1zbaprovided by ZNC
Official Full Name: major histocompatibility complex class I ZBAprovided by ZNC
Primary source: ZFIN:ZDB-GENE-040426-2149
See related: Ensembl:ENSDARG00000036588 AllianceGenome:ZFIN:ZDB-GENE-040426-2149
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: hlazel; zgc:64115
Summary: Predicted to be involved in immune response. Predicted to be located in membrane. Predicted to be active in external side of plasma membrane and extracellular space. Is expressed in gill; intestine; kidney; liver; and spleen. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); asthma (multiple); autoimmune disease (multiple); eye disease (multiple); and inner ear disease (multiple). Orthologous to several human genes including HLA-A (major histocompatibility complex, class I, A); HLA-B (major histocompatibility complex, class I, B); and HLA-C (major histocompatibility complex, class I, C). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

Location:: chromosome: 1

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	1	NC_007112.7 (47155424..47161996, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	1	NC_007112.6 (46464192..46470764, complement)

Chromosome 1 - NC_007112.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

fd56f03.x1 (e-PCR)
- UniSTS:195682

fk85a06.x1 (e-PCR)
- UniSTS:201619

Gene Ontology Provided by ZFIN

Process	Evidence Code	Pubs
involved_in immune response	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in external side of plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: major histocompatibility complex class I ZBA

Names: MHC class I antigen ZBA

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001110118.1 → NP_001103588.1 major histocompatibility complex class I ZBA precursor

See identical proteins and their annotated locations for NP_001103588.1

Status: PROVISIONAL

Source sequence(s)

BX005416

UniProtKB/TrEMBL

A8E7F4, A8KC24

Related

ENSDARP00000053152.4, ENSDART00000053153.6

Conserved Domains (2) summary

cd07698
Location:209 → 304

IgC_MHC_I_alpha3; Class I major histocompatibility complex (MHC) alpha chain immunoglobulin domain

cl08246
Location:22 → 205

MHC_I; Class I Histocompatibility antigen, domains alpha 1 and 2