U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    dhx16 DEAH (Asp-Glu-Ala-His) box polypeptide 16 [ Danio rerio (zebrafish) ]

    Gene ID: 336645, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    dhx16provided by ZNC
    Official Full Name
    DEAH (Asp-Glu-Ala-His) box polypeptide 16provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-8589
    See related
    Ensembl:ENSDARG00000013150 AllianceGenome:ZFIN:ZDB-GENE-030131-8589
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    fa91b12; zgc:55590; wu:fa91b12
    Summary
    Predicted to enable RNA binding activity and helicase activity. Acts upstream of or within endodermal cell differentiation. Orthologous to human DHX16 (DEAH-box helicase 16). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See dhx16 in Genome Data Viewer
    Location:
    chromosome: 15
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 15 NC_007126.7 (34899643..34933560, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 15 NC_007126.6 (35041236..35075591, complement)

    Chromosome 15 - NC_007126.7Genomic Context describing neighboring genes Neighboring gene alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase a Neighboring gene ring finger protein 183 Neighboring gene lysosomal thioesterase PPT2-like Neighboring gene palmitoyl-protein thioesterase 2a, tandem duplicate 1 Neighboring gene palmitoyl-protein thioesterase 2a, tandem duplicate 2

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Identification of recessive maternal-effect mutations in the zebrafish using a gynogenesis-based method. Pelegri F, et al. Dev Dyn, 2004 Oct. PMID 15366009
    2. In vitro oocyte culture-based manipulation of zebrafish maternal genes. Nair S, et al. Dev Dyn, 2013 Jan. PMID 23074011, Free PMC Article
    3. A genome-wide survey of Major Histocompatibility Complex (MHC) genes and their paralogues in zebrafish. Sambrook JG, et al. BMC Genomics, 2005 Nov 4. PMID 16271140, Free PMC Article
    4. The zebrafish maternal-effect gene mission impossible encodes the DEAH-box helicase Dhx16 and is essential for the expression of downstream endodermal genes. Putiri E, et al. Dev Biol, 2011 May 15. PMID 21396359, Free PMC Article
    5. Identification of 315 genes essential for early zebrafish development. Amsterdam A, et al. Proc Natl Acad Sci U S A, 2004 Aug 31. PMID 15256591, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Within the endoderm induction pathway, mis is not required for the activation of early zygotic genes, but is essential to implement nodal activity downstream of casanova/sox 32 but upstream of sox17 expression
      Title: The zebrafish maternal-effect gene mission impossible encodes the DEAH-box helicase Dhx16 and is essential for the expression of downstream endodermal genes.
    Submit: New GeneRIF Correction

    Pathways from PubChem

    Go to the top of the page

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA helicase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables helicase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables helicase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within RNA splicing IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within endodermal cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within mRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16
    Names
    mis
    mission impossible
    NP_956318.1
    XP_068069578.1

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_200024.1 → NP_956318.1  pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16

      See identical proteins and their annotated locations for NP_956318.1

      Status: PROVISIONAL

      Source sequence(s)
      BC045393
      UniProtKB/TrEMBL
      Q7ZVV8
      Related
      ENSDARP00000002154.9, ENSDART00000006288.10
      Conserved Domains (8) summary
      smart00487
      Location:407 → 594
      DEXDc; DEAD-like helicases superfamily
      smart00847
      Location:811 → 895
      HA2; Helicase associated domain (HA2) Add an annotation
      cd00046
      Location:429 → 568
      DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
      pfam00271
      Location:612 → 742
      Helicase_C; Helicase conserved C-terminal domain
      pfam06375
      Location:94 → 142
      BLVR; Bovine leukaemia virus receptor (BLVR)
      pfam07717
      Location:916 → 1028
      OB_NTP_bind; Oligonucleotide/oligosaccharide-binding (OB)-fold
      cd16269
      Location:271 → 285
      GBP_C; coiled coil [structural motif]
      cl20817
      Location:177 → 296
      GBP_C; Guanylate-binding protein, C-terminal domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007126.7 Reference GRCz11 Primary Assembly

      Range
      34899643..34933560 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_068213477.1 → XP_068069578.1  pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16 isoform X1

    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Tools