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    rhot1a ras homolog family member T1a [ Danio rerio (zebrafish) ]

    Gene ID: 327143, updated on 9-Dec-2024

    Summary

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    Official Symbol
    rhot1aprovided by ZNC
    Official Full Name
    ras homolog family member T1aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-5354
    See related
    Ensembl:ENSDARG00000099996 AllianceGenome:ZFIN:ZDB-GENE-030131-5354
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    miro1; rhot1; zgc:55581; zgc:77063; wu:fd14e11; wu:fi14a05
    Summary
    Predicted to enable GTP binding activity and GTPase activity. Predicted to be involved in cellular homeostasis; mitochondrial outer membrane permeabilization; and mitochondrion transport along microtubule. Predicted to act upstream of or within small GTPase-mediated signal transduction. Located in mitochondrion. Is expressed in fin bud; head; muscle; and somite. Orthologous to human RHOT1 (ras homolog family member T1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See rhot1a in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 3 NC_007114.7 (26288981..26319758)
    105 previous assembly GRCz10 (GCF_000002035.5) 3 NC_007114.6 (26158084..26188887)

    Chromosome 3 - NC_007114.7Genomic Context describing neighboring genes Neighboring gene ATPase family AAA domain containing 5a Neighboring gene ArfGAP with dual PH domains 2 Neighboring gene uncharacterized LOC100331676 Neighboring gene zgc:153240

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Characterization of the three zebrafish orthologs of the mitochondrial GTPase Miro/Rhot. Hollister BM, et al. Comp Biochem Physiol B Biochem Mol Biol, 2016 Jan. PMID 26482085
    2. Mitochondria in Embryogenesis: An Organellogenesis Perspective. Arribat Y, et al. Front Cell Dev Biol, 2019. PMID 31824944, Free PMC Article
    3. Genomic annotation and expression analysis of the zebrafish Rho small GTPase family during development and bacterial infection. Salas-Vidal E, et al. Genomics, 2005 Jul. PMID 15894457
    4. Xmrk, kras and myc transgenic zebrafish liver cancer models share molecular signatures with subsets of human hepatocellular carcinoma. Zheng W, et al. PLoS One, 2014. PMID 24633177, Free PMC Article
    5. Targeted Gene Expression in Zebrafish Exposed to Chlorpyrifos-Oxon Confirms Phenotype-Specific Mechanisms Leading to Adverse Outcomes. Garcia-Reyero N, et al. Bull Environ Contam Toxicol, 2016 Jun. PMID 27086301, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables GTP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular homeostasis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in mitochondrial outer membrane permeabilization ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in mitochondrion organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within mitochondrion organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitochondrion transport along microtubule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitochondrion transport along microtubule ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within small GTPase-mediated signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in mitochondrial outer membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrial outer membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrial outer membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    mitochondrial Rho GTPase 1-A
    Names
    MIRO-1-A
    ras homolog gene family member T1-A
    ras homolog gene family, member T1
    ras homolog gene family, member T1a
    NP_997869.1
    XP_009297700.1
    XP_009297701.1
    XP_009297702.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_212704.1 → NP_997869.1  mitochondrial Rho GTPase 1-A

      See identical proteins and their annotated locations for NP_997869.1

      Status: PROVISIONAL

      Source sequence(s)
      BC068190
      UniProtKB/Swiss-Prot
      Q6NVC5, Q803L2
      Related
      ENSDARP00000141563.1, ENSDART00000163500.3
      Conserved Domains (6) summary
      smart00174
      Location:7 → 169
      RHO; Rho (Ras homology) subfamily of Ras-like small GTPases
      cd01892
      Location:415 → 593
      Miro2; Mitochondrial Rho family 2 (Miro2), C-terminal
      cd01893
      Location:3 → 169
      Miro1; Mitochondrial Rho family 1 (Miro1), N-terminal
      COG1100
      Location:418 → 537
      Gem1; GTPase SAR1 family domain [General function prediction only]
      pfam08355
      Location:341 → 409
      EF_assoc_1; EF hand associated
      pfam08356
      Location:221 → 301
      EF_assoc_2; EF hand associated

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007114.7 Reference GRCz11 Primary Assembly

      Range
      26288981..26319758
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_009299425.4 → XP_009297700.1  mitochondrial Rho GTPase 1-A isoform X1

      UniProtKB/TrEMBL
      A0A8M3B899
      Conserved Domains (6) summary
      smart00174
      Location:7 → 169
      RHO; Rho (Ras homology) subfamily of Ras-like small GTPases
      cd01892
      Location:415 → 582
      Miro2; Mitochondrial Rho family 2 (Miro2), C-terminal
      cd01893
      Location:3 → 169
      Miro1; Mitochondrial Rho family 1 (Miro1), N-terminal
      COG1100
      Location:418 → 537
      Gem1; GTPase SAR1 family domain [General function prediction only]
      pfam08355
      Location:341 → 409
      EF_assoc_1; EF hand associated
      pfam08356
      Location:221 → 301
      EF_assoc_2; EF hand associated

    2. XM_009299426.4 → XP_009297701.1  mitochondrial Rho GTPase 1-A isoform X2

      UniProtKB/TrEMBL
      A0A8M3AQV6
      Conserved Domains (6) summary
      smart00174
      Location:7 → 169
      RHO; Rho (Ras homology) subfamily of Ras-like small GTPases
      cd01892
      Location:415 → 582
      Miro2; Mitochondrial Rho family 2 (Miro2), C-terminal
      cd01893
      Location:3 → 169
      Miro1; Mitochondrial Rho family 1 (Miro1), N-terminal
      COG1100
      Location:418 → 537
      Gem1; GTPase SAR1 family domain [General function prediction only]
      pfam08355
      Location:341 → 409
      EF_assoc_1; EF hand associated
      pfam08356
      Location:221 → 301
      EF_assoc_2; EF hand associated

    3. XM_009299427.4 → XP_009297702.1  mitochondrial Rho GTPase 1-A isoform X3

      UniProtKB/TrEMBL
      A0A8M3B0X9
      Conserved Domains (6) summary
      smart00174
      Location:7 → 169
      RHO; Rho (Ras homology) subfamily of Ras-like small GTPases
      cd01892
      Location:415 → 582
      Miro2; Mitochondrial Rho family 2 (Miro2), C-terminal
      cd01893
      Location:3 → 169
      Miro1; Mitochondrial Rho family 1 (Miro1), N-terminal
      COG1100
      Location:418 → 537
      Gem1; GTPase SAR1 family domain [General function prediction only]
      pfam08355
      Location:341 → 409
      EF_assoc_1; EF hand associated
      pfam08356
      Location:221 → 301
      EF_assoc_2; EF hand associated
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6NVC5.1 GenPept UniProtKB/Swiss-Prot:Q6NVC5

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