U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    vil1 villin 1 [ Danio rerio (zebrafish) ]

    Gene ID: 393207, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    vil1provided by ZNC
    Official Full Name
    villin 1provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040426-799
    See related
    Ensembl:ENSDARG00000040466 AllianceGenome:ZFIN:ZDB-GENE-040426-799
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    vil1l; zgc:55779
    Summary
    Predicted to enable actin filament binding activity and phosphatidylinositol-4,5-bisphosphate binding activity. Predicted to be involved in several processes, including actin polymerization or depolymerization; barbed-end actin filament capping; and regulation of lamellipodium morphogenesis. Predicted to act upstream of or within actin filament capping and cytoskeleton organization. Predicted to be located in filopodium tip; microvillus; and ruffle. Predicted to be active in actin cytoskeleton; cytoplasm; and lamellipodium. Is expressed in gut epithelium; intestinal epithelium; and intestine. Orthologous to human VIL1 (villin 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See vil1 in Genome Data Viewer
    Location:
    chromosome: 9
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 9 NC_007120.7 (44910768..44953404, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 9 NC_007120.6 (45109816..45152485, complement)

    Chromosome 9 - NC_007120.7Genomic Context describing neighboring genes Neighboring gene DnaJ (Hsp40) homolog, subfamily C, member 10 Neighboring gene zgc:66484 Neighboring gene integrin, beta 2 Neighboring gene retinol saturase (all-trans-retinol 13,14-reductase) like

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Target of rapamycin (TOR) signaling controls epithelial morphogenesis in the vertebrate intestine. Makky K, et al. Dev Biol, 2007 Mar 15. PMID 17222402, Free PMC Article
    2. Dysregulated phosphatidylinositol signaling promotes endoplasmic-reticulum-stress-mediated intestinal mucosal injury and inflammation in zebrafish. Thakur PC, et al. Dis Model Mech, 2014 Jan. PMID 24135483, Free PMC Article
    3. Smooth muscle caldesmon modulates peristalsis in the wild type and non-innervated zebrafish intestine. Abrams J, et al. Neurogastroenterol Motil, 2012 Mar. PMID 22316291, Free PMC Article
    4. Transgenic overexpression of cdx1b induces metaplastic changes of gene expression in zebrafish esophageal squamous epithelium. Hu B, et al. Zebrafish, 2013 Jun. PMID 23672288, Free PMC Article
    5. Morphological and molecular evidence for functional organization along the rostrocaudal axis of the adult zebrafish intestine. Wang Z, et al. BMC Genomics, 2010 Jun 22. PMID 20565988, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

    Go to the top of the page

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Clone Names

    • MGC55779

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables actin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables actin filament binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables actin filament binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphatidylinositol-4,5-bisphosphate binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within actin filament capping IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in actin filament severing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in actin polymerization or depolymerization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in barbed-end actin filament capping IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within cytoskeleton organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of lamellipodium morphogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in actin cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in filopodium tip IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in lamellipodium IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in microvillus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in ruffle IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    villin-1
    Names
    villin 1 like

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_200238.1 → NP_956532.1  villin-1

      See identical proteins and their annotated locations for NP_956532.1

      Status: PROVISIONAL

      Source sequence(s)
      BC047186
      UniProtKB/TrEMBL
      Q802V3
      Related
      ENSDARP00000059227.4, ENSDART00000059228.6
      Conserved Domains (7) summary
      cd11288
      Location:515 → 605
      gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
      cd11289
      Location:139 → 225
      gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
      cd11290
      Location:18 → 122
      gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
      cd11291
      Location:621 → 717
      gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins
      cd11292
      Location:252 → 350
      gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
      cd11293
      Location:394 → 494
      gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
      pfam02209
      Location:800 → 834
      VHP; Villin headpiece domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007120.7 Reference GRCz11 Primary Assembly

      Range
      44910768..44953404 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005167920.5 → XP_005167977.1  villin-1 isoform X1

      UniProtKB/TrEMBL
      A0A8M2BFE1, F1QVU3
      Related
      ENSDARP00000153798.1, ENSDART00000185210.1
      Conserved Domains (7) summary
      cd11288
      Location:515 → 605
      gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
      cd11289
      Location:139 → 225
      gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
      cd11290
      Location:18 → 122
      gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
      cd11291
      Location:621 → 717
      gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins
      cd11292
      Location:252 → 350
      gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
      cd11293
      Location:394 → 494
      gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
      pfam02209
      Location:800 → 834
      VHP; Villin headpiece domain
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.