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    lrp1aa low density lipoprotein receptor-related protein 1Aa [ Danio rerio (zebrafish) ]

    Gene ID: 563149, updated on 4-Jan-2025

    Summary

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    Official Symbol
    lrp1aaprovided by ZNC
    Official Full Name
    low density lipoprotein receptor-related protein 1Aaprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-7889
    See related
    Ensembl:ENSDARG00000097827 AllianceGenome:ZFIN:ZDB-GENE-030131-7889
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    lrp1a; wu:fj39b01; si:dkey-40c23.4
    Summary
    Predicted to enable calcium ion binding activity. Acts upstream of or within regulation of vasculature development. Predicted to be located in membrane. Is expressed in blood vessel and caudal vein plexus. Human ortholog(s) of this gene implicated in Alzheimer's disease; keratosis pilaris atrophicans; myocardial infarction; and sciatic neuropathy. Orthologous to human LRP1 (LDL receptor related protein 1). [provided by Alliance of Genome Resources, Jan 2025]
    Annotation information
    Annotation category: partial on reference assembly
    Orthologs
    all
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    Genomic context

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    See lrp1aa in Genome Data Viewer
    Location:
    chromosome: 11
    Exon count:
    87
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 11 NC_007122.7 (1628539..1864384)
    105 previous assembly GRCz10 (GCF_000002035.5) 11 NC_007122.6 (1601937..1867395)

    Chromosome 11 - NC_007122.7Genomic Context describing neighboring genes Neighboring gene deltex E3 ubiquitin ligase 3L b, tandem duplicate 2 Neighboring gene deltex E3 ubiquitin ligase 3L b, tandem duplicate 3 Neighboring gene RNA binding motif, single stranded interacting protein 2a Neighboring gene Fas apoptotic inhibitory molecule 2b

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. LRP1-dependent endocytic mechanism governs the signaling output of the bmp system in endothelial cells and in angiogenesis. Pi X, et al. Circ Res, 2012 Aug 17. PMID 22777006, Free PMC Article
    2. CRISPR gRNA phenotypic screening in zebrafish reveals pro-regenerative genes in spinal cord injury. Keatinge M, et al. PLoS Genet, 2021 Apr. PMID 33914736, Free PMC Article
    3. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
    5. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in animal organ development IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within endocytosis IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within regulation of vasculature development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    LOW QUALITY PROTEIN: low-density lipoprotein receptor-related protein 1
    Names
    low density lipoprotein receptor-related protein 1a

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007122.7 Reference GRCz11 Primary Assembly

      Range
      1628539..1864384
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021479679.2 → XP_021335354.1  LOW QUALITY PROTEIN: low-density lipoprotein receptor-related protein 1

      UniProtKB/TrEMBL
      A0A8M9QD95
      Related
      ENSDARP00000133829.2, ENSDART00000164394.2
      Conserved Domains (9) summary
      smart00192
      Location:2818 → 2850
      LDLa; Low-density lipoprotein receptor domain class A
      smart00135
      Location:3183 → 3224
      LY; Low-density lipoprotein-receptor YWTD domain
      smart00179
      Location:2983 → 3013
      EGF_CA; Calcium-binding EGF-like domain
      cd00112
      Location:3537 → 3571
      LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
      pfam00058
      Location:4014 → 4054
      Ldl_recept_b; Low-density lipoprotein receptor repeat class B
      cl00104
      Location:2530 → 2559
      LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
      pfam12662
      Location:2963 → 2986
      cEGF; Complement Clr-like EGF-like
      pfam14670
      Location:3295 → 3331
      FXa_inhibition; Coagulation Factor Xa inhibitory site
      cl26742
      Location:2235 → 2439
      SGL; SMP-30/Gluconolaconase/LRE-like region
    Nucleotide Protein Strain
    Heading Accession and Version

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