rgs2 regulator of G protein signaling 2 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: rgs2provided by ZNC
Official Full Name: regulator of G protein signaling 2provided by ZNC
Primary source: ZFIN:ZDB-GENE-040718-410
See related: Ensembl:ENSDARG00000098761 AllianceGenome:ZFIN:ZDB-GENE-040718-410
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: fa96c08; zgc:91965; wu:fa96c08; wu:fj08f11
Summary: Predicted to enable GTPase activator activity. Acts upstream of or within negative regulation of neural crest formation and neural crest cell development. Predicted to be located in cytoplasm; membrane; and nucleus. Is expressed in cephalic mesoderm; digestive system; nervous system; and neural crest cell. Orthologous to human RGS2 (regulator of G protein signaling 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: chromosome: 22

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	22	NC_007133.7 (24246213..24248422, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	22	NC_007133.6 (24219649..24221858, complement)

Chromosome 22 - NC_007133.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

This study reveals a unique regulatory mechanism, the Rgs2-Ppard-Sox10 signaling cascade, and defines a key molecular regulator, Rgs2, in neural crest development.
Title: Regulator of G protein signaling 2 (Rgs2) regulates neural crest development through Pparδ-Sox10 cascade.

Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Markers

fj08f11.x1 (e-PCR)
- UniSTS:198469

AI332002 (e-PCR)
- UniSTS:206784

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables GTPase activator activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within negative regulation of neural crest formation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within neural crest cell development	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

Go to the top of the page Help

Preferred Names: regulator of G-protein signaling 2

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001002662.2 → NP_001002662.2 regulator of G-protein signaling 2

Status: VALIDATED

Source sequence(s)

BC076456, BX649608

UniProtKB/TrEMBL

A0A8M1N0Y4, Q6DG95

Related

ENSDARP00000130022.1, ENSDART00000165433.2

Conserved Domains (1) summary

cl02565
Location:77 → 189

RGS; Regulator of G protein signaling (RGS) domain superfamily