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    eif2s1b eukaryotic translation initiation factor 2, subunit 1 alpha b [ Danio rerio (zebrafish) ]

    Gene ID: 321564, updated on 9-Dec-2024

    Summary

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    Official Symbol
    eif2s1bprovided by ZNC
    Official Full Name
    eukaryotic translation initiation factor 2, subunit 1 alpha bprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-283
    See related
    Ensembl:ENSDARG00000052178 AllianceGenome:ZFIN:ZDB-GENE-030131-283
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    eif2; eif2s1; fb19d01; wu:fb19d01
    Summary
    Predicted to enable ribosome binding activity and translation initiation factor activity. Predicted to be involved in translational initiation. Predicted to act upstream of or within translation. Predicted to be located in cytoplasm. Predicted to be part of eukaryotic 48S preinitiation complex and eukaryotic translation initiation factor 2 complex. Is expressed in several structures, including immature eye; musculature system; nervous system; pharyngeal arch 3-7 skeleton; and segmental plate. Human ortholog(s) of this gene implicated in Alzheimer's disease. Orthologous to human EIF2S1 (eukaryotic translation initiation factor 2 subunit alpha). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See eif2s1b in Genome Data Viewer
    Location:
    chromosome: 20
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 20 NC_007131.7 (51104367..51123265)
    105 previous assembly GRCz10 (GCF_000002035.5) 20 NC_007131.6 (51291147..51310045)

    Chromosome 20 - NC_007131.7Genomic Context describing neighboring genes Neighboring gene protein associated with LIN7 1, MAGUK p55 family member b Neighboring gene ATPase H+ transporting V1 subunit D Neighboring gene RNA binding motif protein 25b Neighboring gene heat shock protein 90, alpha (cytosolic), class B member 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Characterization of rainbow trout and zebrafish eukaryotic initiation factor 2alpha and its response to endoplasmic reticulum stress and IPNV infection. Garner JN, et al. Dev Comp Immunol, 2003 Mar. PMID 12590973
    2. A truncated Danio rerio PKZ isoform functionally interacts with eIF2α and inhibits protein synthesis. Liu ZY, et al. Gene, 2013 Sep 15. PMID 23742890
    3. Morphological, behavioral and cellular analyses revealed different phenotypes in Wolfram syndrome wfs1a and wfs1b zebrafish mutant lines. Crouzier L, et al. Hum Mol Genet, 2022 Aug 23. PMID 35325133, Free PMC Article
    4. Selective and competitive functions of the AAR and UPR pathways in stress-induced angiogenesis. Zhang F, et al. Cell Discov, 2021 Oct 26. PMID 34697290, Free PMC Article
    5. Slc38a9 Deficiency Induces Apoptosis and Metabolic Dysregulation and Leads to Premature Death in Zebrafish. Wu X, et al. Int J Mol Sci, 2022 Apr 11. PMID 35457018, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC56347

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ribosome binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables translation initiation factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables translation initiation factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in translational initiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within translational initiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cytoplasmic stress granule IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of eukaryotic 48S preinitiation complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of eukaryotic translation initiation factor 2 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    eukaryotic translation initiation factor 2 subunit 1b
    Names
    eIF2 alpha subunit

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_131800.2 → NP_571875.1  eukaryotic translation initiation factor 2 subunit 1b

      See identical proteins and their annotated locations for NP_571875.1

      Status: PROVISIONAL

      Source sequence(s)
      BC051785
      UniProtKB/TrEMBL
      A8E5I4, F6P147, Q9I9E9
      Related
      ENSDARP00000068470.3, ENSDART00000073981.4
      Conserved Domains (3) summary
      cd04452
      Location:14 → 89
      S1_IF2_alpha; S1_IF2_alpha: The alpha subunit of translation Initiation Factor 2, S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. Eukaryotic and archaeal Initiation Factor 2 (e- and aIF2, respectively) ...
      PTZ00248
      Location:4 → 315
      PTZ00248; eukaryotic translation initiation factor 2 subunit 1; Provisional
      pfam07541
      Location:132 → 241
      EIF_2_alpha; Eukaryotic translation initiation factor 2 alpha subunit

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007131.7 Reference GRCz11 Primary Assembly

      Range
      51104367..51123265
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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