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    arhgap11a Rho GTPase activating protein 11A [ Danio rerio (zebrafish) ]

    Gene ID: 406608, updated on 9-Dec-2024

    Summary

    Official Symbol
    arhgap11aprovided by ZNC
    Official Full Name
    Rho GTPase activating protein 11Aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040426-2562
    See related
    Ensembl:ENSDARG00000100019 AllianceGenome:ZFIN:ZDB-GENE-040426-2562
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:77004; wu:fc02e04; wu:fc55g06; wu:fe01b01
    Summary
    Predicted to enable GTPase activator activity. Predicted to act upstream of or within signal transduction. Orthologous to several human genes including ARHGAP11A (Rho GTPase activating protein 11A). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

    See arhgap11a in Genome Data Viewer
    Location:
    chromosome: 17
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 17 NC_007128.7 (92784..114113, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 17 NC_007128.6 (92648..114197, complement)

    Chromosome 17 - NC_007128.7Genomic Context describing neighboring genes Neighboring gene si:ch1073-209e23.1 Neighboring gene gremlin 1b Neighboring gene actin alpha cardiac muscle 1b Neighboring gene leucine rich repeat protein 1 Neighboring gene kelch domain containing 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    General gene information

    Markers

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables GTPase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within signal transduction IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    rho GTPase-activating protein 11A

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001193539.1NP_001180468.1  rho GTPase-activating protein 11A isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      CU655844
      UniProtKB/TrEMBL
      A0A0R4ILK3, A0A8M1NX98
      Related
      ENSDARP00000136955.1, ENSDART00000172408.2
      Conserved Domains (1) summary
      cd04394
      Location:43244
      RhoGAP-ARHGAP11A; RhoGAP-ARHGAP11A: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP11A-like proteins. The mouse homolog of human ArhGAP11A has been detected as a gene exclusively expressed in immature ganglion cells, potentially playing ...
    2. NM_213316.2NP_998481.2  rho GTPase-activating protein 11A isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks two exons and includes an alternate segment in the 3' coding region and 3' UTR, compared to variant 1. It encodes isoform 2, which has a shorter and distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      CU655844
      UniProtKB/TrEMBL
      A0A0R4IMZ9, A0A8N1Z4I6
      Related
      ENSDARP00000137263.1, ENSDART00000157784.2
      Conserved Domains (1) summary
      cd04394
      Location:43244
      RhoGAP-ARHGAP11A; RhoGAP-ARHGAP11A: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP11A-like proteins. The mouse homolog of human ArhGAP11A has been detected as a gene exclusively expressed in immature ganglion cells, potentially playing ...

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007128.7 Reference GRCz11 Primary Assembly

      Range
      92784..114113 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005173570.5XP_005173627.1  rho GTPase-activating protein 11A isoform X1

      UniProtKB/TrEMBL
      A0A8M2BKT8
      Conserved Domains (1) summary
      cd04394
      Location:43244
      RhoGAP-ARHGAP11A; RhoGAP-ARHGAP11A: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP11A-like proteins. The mouse homolog of human ArhGAP11A has been detected as a gene exclusively expressed in immature ganglion cells, potentially playing ...