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    wdhd1 WD repeat and HMG-box DNA binding protein 1 [ Danio rerio (zebrafish) ]

    Gene ID: 436999, updated on 9-Dec-2024

    Summary

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    Official Symbol
    wdhd1provided by ZNC
    Official Full Name
    WD repeat and HMG-box DNA binding protein 1provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-1665
    See related
    Ensembl:ENSDARG00000015998 AllianceGenome:ZFIN:ZDB-GENE-030131-1665
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    AND-1; zgc:92585; wu:fa11f10; wu:fb77d12
    Summary
    Predicted to enable chromatin binding activity. Predicted to be involved in DNA repair; DNA-templated DNA replication; and mitotic cell cycle. Predicted to be located in nucleus. Predicted to be active in nuclear replication fork. Is expressed in proliferative region. Human ortholog(s) of this gene implicated in cholangiocarcinoma. Orthologous to human WDHD1 (WD repeat and HMG-box DNA binding protein 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See wdhd1 in Genome Data Viewer
    Location:
    chromosome: 17
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 17 NC_007128.7 (15149765..15189406, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 17 NC_007128.6 (15141832..15181478, complement)

    Chromosome 17 - NC_007128.7Genomic Context describing neighboring genes Neighboring gene sterile alpha motif domain containing 4A Neighboring gene GTP cyclohydrolase 1 Neighboring gene uncharacterized LOC100499487 Neighboring gene suppressor of cytokine signaling 4 Neighboring gene glucosamine-phosphate N-acetyltransferase 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Evolution of pigment synthesis pathways by gene and genome duplication in fish. Braasch I, et al. BMC Evol Biol, 2007 May 11. PMID 17498288, Free PMC Article
    2. A comparative map of the zebrafish genome. Woods IG, et al. Genome Res, 2000 Dec. PMID 11116086, Free PMC Article
    3. Evolution of JAK-STAT pathway components: mechanisms and role in immune system development. Liongue C, et al. PLoS One, 2012. PMID 22412924, Free PMC Article
    4. 15000 unique zebrafish EST clusters and their future use in microarray for profiling gene expression patterns during embryogenesis. Lo J, et al. Genome Res, 2003 Mar. PMID 12618376, Free PMC Article
    5. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    WD repeat and HMG-box DNA-binding protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001002726.2 → NP_001002726.2  WD repeat and HMG-box DNA-binding protein 1

      Status: VALIDATED

      Source sequence(s)
      CU464134
      UniProtKB/TrEMBL
      A0A0R4J7S6, A0A8M1N0Y6
      Related
      ENSDARP00000113096.2, ENSDART00000133710.4
      Conserved Domains (6) summary
      COG2319
      Location:11 → 299
      WD40; WD40 repeat [General function prediction only]
      COG5648
      Location:922 → 1112
      NHP6B; Chromatin-associated proteins containing the HMG domain [Chromatin structure and dynamics]
      cd00084
      Location:1010 → 1071
      HMG-box; High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I ...
      cd00200
      Location:10 → 289
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      pfam12341
      Location:427 → 709
      Mcl1_mid; Minichromosome loss protein, Mcl1, middle region
      sd00039
      Location:17 → 54
      7WD40; WD40 repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007128.7 Reference GRCz11 Primary Assembly

      Range
      15149765..15189406 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_009292886.4 → XP_009291161.1  WD repeat and HMG-box DNA-binding protein 1 isoform X1

      UniProtKB/TrEMBL
      A0A8M9PNN9
      Conserved Domains (6) summary
      COG5648
      Location:923 → 1113
      NHP6B; Chromatin-associated proteins containing the HMG domain [Chromatin structure and dynamics]
      cd00084
      Location:1011 → 1072
      HMG-box; High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I ...
      cd00200
      Location:10 → 289
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:17 → 54
      7WD40; WD40 repeat [structural motif]
      pfam12341
      Location:427 → 709
      Mcl1_mid; Minichromosome loss protein, Mcl1, middle region
      cl25574
      Location:802 → 1039
      TOP2c; TopoisomeraseII

    2. XM_021467145.2 → XP_021322820.1  WD repeat and HMG-box DNA-binding protein 1 isoform X1

      UniProtKB/TrEMBL
      A0A8M9PNN9
      Conserved Domains (6) summary
      COG5648
      Location:923 → 1113
      NHP6B; Chromatin-associated proteins containing the HMG domain [Chromatin structure and dynamics]
      cd00084
      Location:1011 → 1072
      HMG-box; High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I ...
      cd00200
      Location:10 → 289
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:17 → 54
      7WD40; WD40 repeat [structural motif]
      pfam12341
      Location:427 → 709
      Mcl1_mid; Minichromosome loss protein, Mcl1, middle region
      cl25574
      Location:802 → 1039
      TOP2c; TopoisomeraseII
    Nucleotide Protein Strain
    Heading Accession and Version

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