otop1 otopetrin 1 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: otop1provided by ZNC
Official Full Name: otopetrin 1provided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-1613
See related: AllianceGenome:ZFIN:ZDB-GENE-030131-1613
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: wu:fb76b02; zgc:103626
Summary: Enables cholesterol binding activity; identical protein binding activity; and proton channel activity. Involved in proton transmembrane transport. Acts upstream of or within otolith formation and otolith mineralization. Is active in membrane. Is expressed in lateral line system; otic vesicle; vestibuloauditory system; and yolk syncytial layer. Orthologous to human OTOP1 (otopetrin 1). [provided by Alliance of Genome Resources, Dec 2024]
Annotation information: Annotation category: suggests misassembly; Annotation category: partial on reference assembly
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 14

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	14	NC_007125.7 (49520..58449)
105	previous assembly	GRCz10 (GCF_000002035.5)	14	NC_007125.6 (195917..204846, complement)

Chromosome 14 - NC_007125.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

This study reports the cryo-EM structure of zebrafish Otop1 in lipid nanodiscs. The structures reveal a dimeric architecture, with each subunit forming 12 transmembrane helices divided into structurally similar amino (N) and carboxy (C) domains.
Title: Structures of the otopetrin proton channels Otop1 and Otop3.
Otopetrin 1 in zebrafish may be involved in the protein trafficking of components required for formation of biominerals in the ear.
Title: Mutated otopetrin 1 affects the genesis of otoliths and the localization of Starmaker in zebrafish.
Results demonstrate that otopetrin 1 has an essential and conserved role in the timing of formation and the size and shape of the developing otolith.
Title: Otopetrin 1 is required for otolith formation in the zebrafish Danio rerio.

Submit: New GeneRIF Correction

General gene information

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Markers

fb76b02.x1 (e-PCR)
- UniSTS:191281

fb76b02 (e-PCR)
- UniSTS:187506

Z7811 (e-PCR)
- UniSTS:66948

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables cholesterol binding	IDA Inferred from Direct Assay more info	PubMed
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables proton channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables proton channel activity	IDA Inferred from Direct Assay more info	PubMed
enables proton channel activity	IEA Inferred from Electronic Annotation more info
enables proton channel activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within biomineral tissue development	IEA Inferred from Electronic Annotation more info
involved_in cellular response to insulin stimulus	ISS Inferred from Sequence or Structural Similarity more info
involved_in inner ear morphogenesis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within inner ear morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within monoatomic ion transmembrane transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within monoatomic ion transport	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of type II interferon-mediated signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within otolith formation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within otolith mineralization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in proton transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in proton transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within proton transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in proton transmembrane transport	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in cell projection	IEA Inferred from Electronic Annotation more info
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in membrane	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	ISS Inferred from Sequence or Structural Similarity more info	PubMed
located_in microvillus	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: proton channel OTOP1

Names: 10 transmembrane domains; backstroke; bks; membrane associated

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.