U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    glula glutamate-ammonia ligase (glutamine synthase) a [ Danio rerio (zebrafish) ]

    Gene ID: 100000775, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    glulaprovided by ZNC
    Official Full Name
    glutamate-ammonia ligase (glutamine synthase) aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-688
    See related
    Ensembl:ENSDARG00000099776 AllianceGenome:ZFIN:ZDB-GENE-030131-688
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    gso1; cb195; cb757; fb39g09; fd19d09; sb:cb195; wu:fb39g09; wu:fd19d09; etID49849.2
    Summary
    Predicted to enable glutamine synthetase activity. Predicted to be involved in glutamine biosynthetic process. Predicted to be located in mitochondrion. Predicted to be active in cytoplasm. Is expressed in several structures, including cardiovascular system; digestive system; hematopoietic system; musculature system; and nervous system. Human ortholog(s) of this gene implicated in congenital glutamine deficiency; epilepsy (multiple); heart disease; and neurodegenerative disease (multiple). Orthologous to human GLUL (glutamate-ammonia ligase). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See glula in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 2 NC_007113.7 (18988410..18992347)
    105 previous assembly GRCz10 (GCF_000002035.5) 2 NC_007113.6 (19339346..19343283)

    Chromosome 2 - NC_007113.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC137487787 Neighboring gene uncharacterized LOC137487790 Neighboring gene pre-B-cell leukemia homeobox 1a Neighboring gene transmembrane protein 275a Neighboring gene kinocilin

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Elovl2 Is Required for Robust Visual Function in Zebrafish. Dasyani M, et al. Cells, 2020 Dec 2. PMID 33276584, Free PMC Article
    2. Glutamine synthetase activity and the expression of three glul paralogues in zebrafish during transport. Dhanasiri AK, et al. Comp Biochem Physiol B Biochem Mol Biol, 2012 Nov-Dec. PMID 22750401
    3. A Zebrafish Model of Retinitis Pigmentosa Shows Continuous Degeneration and Regeneration of Rod Photoreceptors. Santhanam A, et al. Cells, 2020 Oct 6. PMID 33036185, Free PMC Article
    4. Differential Apoptotic and Mitogenic Effects of Lectins in Zebrafish. Wang K, et al. Front Endocrinol (Lausanne), 2019. PMID 31231312, Free PMC Article
    5. LIM Homeobox 9 knockdown by morpholino does not affect zebrafish retinal development. Guo R, et al. Biol Open, 2021 Mar 8. PMID 33579692, Free PMC Article

    See all (41) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Clone Names

    • MGC63917

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables catalytic activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glutamine synthetase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glutamine synthetase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in glutamine biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within glutamine biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    glutamate-ammonia ligase (glutamine synthase) a
    Names
    glutamine synthetase 1
    gs
    NP_853537.1

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_181559.2 → NP_853537.1  glutamate-ammonia ligase (glutamine synthase) a

      See identical proteins and their annotated locations for NP_853537.1

      Status: VALIDATED

      Source sequence(s)
      BC171369, EH438060, EH462514
      UniProtKB/TrEMBL
      B7ZUV7, Q7T2P7
      Related
      ENSDARP00000134084.1, ENSDART00000170216.2
      Conserved Domains (3) summary
      PLN02284
      Location:22 → 362
      PLN02284; glutamine synthetase
      pfam00120
      Location:128 → 356
      Gln-synt_C; Glutamine synthetase, catalytic domain
      pfam03951
      Location:30 → 104
      Gln-synt_N; Glutamine synthetase, beta-Grasp domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007113.7 Reference GRCz11 Primary Assembly

      Range
      18988410..18992347
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.