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    msrb3 methionine sulfoxide reductase B3 [ Danio rerio (zebrafish) ]

    Gene ID: 415184, updated on 9-Dec-2024

    Summary

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    Official Symbol
    msrb3provided by ZNC
    Official Full Name
    methionine sulfoxide reductase B3provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040625-74
    See related
    Ensembl:ENSDARG00000045658 AllianceGenome:ZFIN:ZDB-GENE-040625-74
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:86909; wu:fc07g04
    Summary
    Predicted to enable peptide-methionine (R)-S-oxide reductase activity. Acts upstream of or within inner ear development. Predicted to be active in cytoplasm. Is expressed in heart rudiment; heart tube; inner ear; and myotome. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 74. Orthologous to human MSRB3 (methionine sulfoxide reductase B3). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See msrb3 in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 4 NC_007115.7 (12892467..12914192, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 4 NC_007115.6 (12893618..12915343, complement)

    Chromosome 4 - NC_007115.7Genomic Context describing neighboring genes Neighboring gene high mobility group AT-hook 2 Neighboring gene uncharacterized LOC103910419 Neighboring gene LEM domain containing 3 Neighboring gene wnt inhibitory factor 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Down-regulation of msrb3 and destruction of normal auditory system development through hair cell apoptosis in zebrafish. Shen X, et al. Int J Dev Biol, 2015. PMID 26505252
    2. Porcine methionine sulfoxide reductase B3: molecular cloning, tissue-specific expression profiles, and polymorphisms associated with ear size in Sus scrofa. Zhang Y, et al. J Anim Sci Biotechnol, 2015. PMID 26719797, Free PMC Article
    3. Novel Genes Critical for Hypoxic Preconditioning in Zebrafish Are Regulators of Insulin and Glucose Metabolism. Manchenkov T, et al. G3 (Bethesda), 2015 Apr 3. PMID 25840431, Free PMC Article
    4. Thyrotroph embryonic factor regulates light-induced transcription of repair genes in zebrafish embryonic cells. Gavriouchkina D, et al. PLoS One, 2010 Sep 7. PMID 20830285, Free PMC Article
    5. Zebrafish peptidoglycan recognition protein SC (zfPGRP-SC) mediates multiple intracellular signaling pathways. Chang MX, et al. Fish Shellfish Immunol, 2009 Feb. PMID 19084604

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data show that methionine sulfoxide reductase B3 (msrb3) is instrumental for auditory system development in zebrafish.
      Title: Down-regulation of msrb3 and destruction of normal auditory system development through hair cell apoptosis in zebrafish.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables peptide-methionine (R)-S-oxide reductase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables peptide-methionine (R)-S-oxide reductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within inner ear development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within protein repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within response to oxidative stress IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    methionine-R-sulfoxide reductase B3
    NP_001002094.2
    NP_001307307.1
    NP_001307309.1
    XP_009298392.1
    XP_068075682.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001002094.2 → NP_001002094.2  methionine-R-sulfoxide reductase B3 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate exon in the 5' UTR and 5' coding region compared to variant 1. The encoded isoform (2) is shorter and has a distinct N-terminus compared to isoform 1.
      Source sequence(s)
      BX119963
      UniProtKB/TrEMBL
      A0A8M1MZV0, Q5TZH6, Q5TZH7
      Related
      ENSDARP00000120380.1, ENSDART00000145917.3
      Conserved Domains (1) summary
      PRK00222
      Location:35 → 168
      PRK00222; methionine sulfoxide reductase B; Provisional

    2. NM_001320378.1 → NP_001307307.1  methionine-R-sulfoxide reductase B3 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      BX119963
      UniProtKB/TrEMBL
      A0A8M1P8M4, F6P046
      Related
      ENSDARP00000122154.1, ENSDART00000140002.3
      Conserved Domains (1) summary
      PRK00222
      Location:49 → 182
      PRK00222; methionine sulfoxide reductase B; Provisional

    3. NM_001320380.1 → NP_001307309.1  methionine-R-sulfoxide reductase B3 isoform 3 precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an exon in the 5' UTR and 5' coding region which results in the use of an alternate start codon compared to variant 1. The encoded isoform (3) is shorter and has a distinct N-terminus compared to isoform 1.
      Source sequence(s)
      BX119963
      UniProtKB/TrEMBL
      A0A8M1P7N2, Q5TZH8
      Related
      ENSDARP00000123270.2, ENSDART00000141355.3
      Conserved Domains (1) summary
      PRK00222
      Location:36 → 169
      PRK00222; methionine sulfoxide reductase B; Provisional

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007115.7 Reference GRCz11 Primary Assembly

      Range
      12892467..12914192 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_009300117.3 → XP_009298392.1  methionine-R-sulfoxide reductase B3 isoform X1

      See identical proteins and their annotated locations for XP_009298392.1

      UniProtKB/TrEMBL
      A0A8M1P8M4, F6P046
      Conserved Domains (1) summary
      PRK00222
      Location:49 → 182
      PRK00222; methionine sulfoxide reductase B; Provisional

    2. XM_068219581.1 → XP_068075682.1  methionine-R-sulfoxide reductase B3 isoform X2

      UniProtKB/TrEMBL
      A0A8M1MZV0, Q5TZH6, Q5TZH7
      Related
      ENSDARP00000067134.3, ENSDART00000067135.4
    Nucleotide Protein Strain
    Heading Accession and Version

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