klf2a Kruppel like factor 2a [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: klf2aprovided by ZNC
Official Full Name: Kruppel like factor 2aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-011109-1
See related: Ensembl:ENSDARG00000042667 AllianceGenome:ZFIN:ZDB-GENE-011109-1
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: fb08e06; wu:fb08e06; etID35223.22
Summary: Enables transcription cis-regulatory region binding activity. Acts upstream of or within circulatory system development; nitric oxide biosynthetic process; and regulation of cell fate specification. Is expressed in several structures, including EVL; cardiovascular system; cloaca; fin; and pectoral fin bud. Orthologous to human KLF2 (KLF transcription factor 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 22

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	22	NC_007133.7 (15898221..15900919)
105	previous assembly	GRCz10 (GCF_000002035.5)	22	NC_007133.6 (15871951..15874649)

Chromosome 22 - NC_007133.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Primary cilia mediate Klf2-dependant Notch activation in regenerating heart.
Title: Primary cilia mediate Klf2-dependant Notch activation in regenerating heart.
Piezo controls Klf2 and Notch activity in the endothelium and Yap1 localization in the smooth muscle progenitors to coordinate zebrafish outflow tract valve morphogenesis.
Title: Mechanically activated piezo channels modulate outflow tract valve development through the Yap1 and Klf2-Notch signaling axis.
The data suggest that flow-induced ERK5-klf2a-nos2b signaling is involved in CVP angiogenesis in zebrafish embryos.
Title: Blood Flow Regulates Zebrafish Caudal Vein Plexus Angiogenesis by ERK5-klf2a-nos2b Signaling.
These studies provide new insights into how Klf2 regulates cardiovascular development and specifically myocardial wall integrity.
Title: The flow responsive transcription factor Klf2 is required for myocardial wall integrity by modulating Fgf signaling.
Heart valves originate from progenitors located in the ventricle and atrium that generate the valve leaflets through a coordinated set of endocardial tissue movements, dependent on the expression of fibronectin1b. Blood flow and klf2a control these cell behaviours and fibronectin1b synthesis.
Title: klf2a couples mechanotransduction and zebrafish valve morphogenesis through fibronectin synthesis.
In turn, Heg1 stabilizes levels of Krit1 protein, and both Heg1 and Krit1 dampen expression levels of klf2a, a major mechanosensitive gene. The correct balance of blood-flow-dependent induction and Krit1 protein-mediated repression of klf2a and notch1b ultimately shapes cardiac valve leaflet morphology.
Title: Heg1 and Ccm1/2 proteins control endocardial mechanosensitivity during zebrafish valvulogenesis.
reveals a beta1 integrin-Klf2-Egfl7-signaling pathway that is tightly regulated by cerebral cavernous malformation proteins
Title: Regulation of β1 integrin-Klf2-mediated angiogenesis by CCM proteins.
The klf2ash317 mutation produces a truncated Klf2a protein but, unlike morpholino induced klf2a knockdown, does not affect cardiovascular development.
Title: klf2ash317 Mutant Zebrafish Do Not Recapitulate Morpholino-Induced Vascular and Haematopoietic Phenotypes.
Oscillatory flow modulates mechanosensitive klf2a expression through trpv4 and trpp2 during heart valve development.
Title: Oscillatory Flow Modulates Mechanosensitive klf2a Expression through trpv4 and trpp2 during Heart Valve Development.
Klf2a is an important regulator of endocardial cell morphology.
Title: Blood flow and Bmp signaling control endocardial chamber morphogenesis.

Submit: New GeneRIF Correction See all GeneRIFs (14)

General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables transcription cis-regulatory region binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within angiogenesis	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within atrioventricular valve development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within atrioventricular valve morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within endocardial cushion cell development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within heart development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within negative regulation of mesodermal cell fate specification	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within nitric oxide biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of ectodermal cell fate specification	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within ventricular compact myocardium morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed

General protein information

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Preferred Names: Krueppel-like factor 2a

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_131856.3 → NP_571931.2 Krueppel-like factor 2a

See identical proteins and their annotated locations for NP_571931.2

Status: VALIDATED

Source sequence(s)

BX323550, BX908392

UniProtKB/TrEMBL

Q1LXI7, Q1MT81

Related

ENSDARP00000062586.5, ENSDART00000062587.6

Conserved Domains (3) summary

COG5048
Location:273 → 364

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:302 → 321

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam13465
Location:343 → 368

zf-H2C2_2; Zinc-finger double domain