U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    glrx5 glutaredoxin 5 homolog (S. cerevisiae) [ Danio rerio (zebrafish) ]

    Gene ID: 406294, updated on 9-Dec-2024

    Summary

    Official Symbol
    glrx5provided by ZNC
    Official Full Name
    glutaredoxin 5 homolog (S. cerevisiae)provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040426-1957
    See related
    Ensembl:ENSDARG00000043665 AllianceGenome:ZFIN:ZDB-GENE-040426-1957
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    grx5; zgc:73343; id:ibd5119; wu:fa09g08
    Summary
    Predicted to enable 2 iron, 2 sulfur cluster binding activity and metal ion binding activity. Acts upstream of or within hemopoiesis and iron-sulfur cluster assembly. Located in mitochondrion. Is expressed in cardiovascular system; immature eye; intermediate cell mass of mesoderm; and liver. Human ortholog(s) of this gene implicated in autosomal recessive pyridoxine-refractory sideroblastic anemia 3. Orthologous to human GLRX5 (glutaredoxin 5). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See glrx5 in Genome Data Viewer
    Location:
    chromosome: 20
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 20 NC_007131.7 (10484017..10487887, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 20 NC_007131.6 (10496777..10500647, complement)

    Chromosome 20 - NC_007131.7Genomic Context describing neighboring genes Neighboring gene si:dkey-63b1.1 Neighboring gene uncharacterized protein C14orf132-like Neighboring gene uncharacterized LOC137488604 Neighboring gene small Cajal body-specific RNA 13 Neighboring gene lincRNA gene 5888 Neighboring gene calmin b

    Genomic regions, transcripts, and products

    Expression

    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Pathways from PubChem

    General gene information

    Markers

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables 2 iron, 2 sulfur cluster binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables iron-sulfur cluster binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within hemopoiesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within iron-sulfur cluster assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in mitochondrial matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    glutaredoxin-related protein 5, mitochondrial
    Names
    monothiol glutaredoxin-5
    shiraz
    shz

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_213021.1NP_998186.1  glutaredoxin-related protein 5, mitochondrial

      See identical proteins and their annotated locations for NP_998186.1

      Status: PROVISIONAL

      Source sequence(s)
      BC059659
      UniProtKB/Swiss-Prot
      Q6PBM1
      Related
      ENSDARP00000064111.4, ENSDART00000064112.5
      Conserved Domains (1) summary
      cd03028
      Location:45135
      GRX_PICOT_like; Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain ...

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007131.7 Reference GRCz11 Primary Assembly

      Range
      10484017..10487887 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)