cst3 cystatin C (amyloid angiopathy and cerebral hemorrhage) [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: cst3provided by ZNC
Official Full Name: cystatin C (amyloid angiopathy and cerebral hemorrhage)provided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-373
See related: Ensembl:ENSDARG00000007795 AllianceGenome:ZFIN:ZDB-GENE-030131-373
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: fb51d07; wu:fb24g06; wu:fb51d07; wu:fc55f03; zgc:136227
Summary: Predicted to enable cysteine-type endopeptidase inhibitor activity. Predicted to be active in cytoplasm; extracellular space; and vesicle. Human ortholog(s) of this gene implicated in CST3-related cerebral amyloid angiopathy and age related macular degeneration 11. Orthologous to human CST3 (cystatin C). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 13

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	13	NC_007124.7 (33681873..33683913, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	13	NC_007124.6 (33572328..33574368, complement)

Chromosome 13 - NC_007124.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

AI396657 (e-PCR)
- UniSTS:206696

AI477278 (e-PCR)
- UniSTS:206497

fc55f03 (e-PCR)
- UniSTS:189362

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables cysteine-type endopeptidase inhibitor activity	IBA Inferred from Biological aspect of Ancestor more info
enables cysteine-type endopeptidase inhibitor activity	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
is_active_in vesicle	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: cystatin C (amyloid angiopathy and cerebral hemorrhage)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001031673.2 → NP_001026843.2 cystatin C (amyloid angiopathy and cerebral hemorrhage) precursor

Status: VALIDATED

Source sequence(s)

EB868200, EH523905

UniProtKB/TrEMBL

A0A8M1N7I0, B8A4C9

Related

ENSDARP00000065434.5, ENSDART00000065435.6

Conserved Domains (1) summary

smart00043
Location:20 → 128

CY; Cystatin-like domain