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    tjp2a tight junction protein 2a (zona occludens 2) [ Danio rerio (zebrafish) ]

    Gene ID: 565446, updated on 9-Dec-2024

    Summary

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    Official Symbol
    tjp2aprovided by ZNC
    Official Full Name
    tight junction protein 2a (zona occludens 2)provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-070925-2
    See related
    Ensembl:ENSDARG00000063309 AllianceGenome:ZFIN:ZDB-GENE-070925-2
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    tjp2.1; zo-2.1; wu:fb10a11
    Summary
    Predicted to enable cell adhesion molecule binding activity. Predicted to be involved in several processes, including establishment of endothelial intestinal barrier; positive regulation of blood-brain barrier permeability; and protein localization to cell-cell junction. Predicted to be located in anchoring junction and membrane. Predicted to be active in bicellular tight junction and plasma membrane. Is expressed in several structures, including digestive system; epidermis; nervous system; pronephros; and vasculature. Human ortholog(s) of this gene implicated in disease of metabolism and progressive familial intrahepatic cholestasis 4. Orthologous to human TJP2 (tight junction protein 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See tjp2a in Genome Data Viewer
    Location:
    chromosome: 10
    Exon count:
    27
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 10 NC_007121.7 (15815865..15879596, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 10 NC_007121.6 (15857746..15921477, complement)

    Chromosome 10 - NC_007121.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC565709 Neighboring gene amyloid beta (A4) precursor protein-binding, family A, member 1b Neighboring gene phosphatidylinositol-4-phosphate 5-kinase, type I, beta a Neighboring gene si:dkey-3h23.2 Neighboring gene uncharacterized LOC101886624

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identification, tissue distribution and developmental expression of tjp1/zo-1, tjp2/zo-2 and tjp3/zo-3 in the zebrafish, Danio rerio. Kiener TK, et al. Gene Expr Patterns, 2007 Aug. PMID 17632043
    2. Mechanosensation of Tight Junctions Depends on ZO-1 Phase Separation and Flow. Schwayer C, et al. Cell, 2019 Oct 31. PMID 31675500
    3. Blood Flow Suppresses Vascular Anomalies in a Zebrafish Model of Cerebral Cavernous Malformations. Rödel CJ, et al. Circ Res, 2019 Oct 25. PMID 31495257
    4. Modulation of Zebrafish (Danio rerio) Intestinal Mucosal Barrier Function Fed Different Postbiotics and a Probiotic from Lactobacilli. Rawling M, et al. Microorganisms, 2023 Nov 30. PMID 38138044, Free PMC Article
    5. Post-GWAS screening of candidate genes for refractive error in mutant zebrafish models. Quint WH, et al. Sci Rep, 2023 Feb 3. PMID 36737489, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Component Evidence Code Pubs
    located_in anchoring junction IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in bicellular tight junction IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    tight junction protein ZO-2a

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001201570.1 → NP_001188499.1  tight junction protein ZO-2a isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the shorter transcript and encodes the longer isoform (1).
      Source sequence(s)
      BX629350, BX640481
      UniProtKB/TrEMBL
      A0A8M1P3J1, E7FBB9
      Related
      ENSDARP00000086775.5, ENSDART00000092343.6
      Conserved Domains (6) summary
      PHA02896
      Location:136 → 292
      PHA02896; A-type inclusion like protein; Provisional
      smart00072
      Location:749 → 927
      GuKc; Guanylate kinase homologues
      cd00992
      Location:32 → 117
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00625
      Location:778 → 926
      Guanylate_kin; Guanylate kinase
      pfam08648
      Location:179 → 275
      DUF1777; Protein of unknown function (DUF1777)
      cl17036
      Location:650 → 715
      SH3; Src Homology 3 domain superfamily

    2. NM_001201571.1 → NP_001188500.1  tight junction protein ZO-2a isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks the first 5' exon, includes two non-coding 5' exons and uses a downstream start codon, compared to variant 1. The resulting protein (isoform 2) is shorter, compared to isoform 1.
      Source sequence(s)
      BX629350, BX640481
      UniProtKB/TrEMBL
      A0A8M1P2I3, F6PEN0
      Related
      ENSDARP00000119264.1, ENSDART00000136789.2
      Conserved Domains (6) summary
      PHA02896
      Location:113 → 269
      PHA02896; A-type inclusion like protein; Provisional
      smart00072
      Location:726 → 904
      GuKc; Guanylate kinase homologues
      cd00992
      Location:9 → 94
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00625
      Location:755 → 903
      Guanylate_kin; Guanylate kinase
      pfam08648
      Location:156 → 252
      DUF1777; Protein of unknown function (DUF1777)
      cl17036
      Location:627 → 692
      SH3; Src Homology 3 domain superfamily

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007121.7 Reference GRCz11 Primary Assembly

      Range
      15815865..15879596 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_009305192.4 → XP_009303467.1  tight junction protein ZO-2a isoform X1

      UniProtKB/TrEMBL
      A0A8M3B637
      Conserved Domains (6) summary
      PHA02896
      Location:195 → 351
      PHA02896; A-type inclusion like protein; Provisional
      smart00072
      Location:808 → 986
      GuKc; Guanylate kinase homologues
      cd00992
      Location:91 → 176
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00625
      Location:837 → 985
      Guanylate_kin; Guanylate kinase
      pfam08648
      Location:238 → 334
      DUF1777; Protein of unknown function (DUF1777)
      cl17036
      Location:709 → 774
      SH3; Src Homology 3 domain superfamily

    2. XM_005155574.5 → XP_005155631.1  tight junction protein ZO-2a isoform X2

      UniProtKB/TrEMBL
      A0A2R8QB05, A0A8M2B1S6
      Related
      ENSDARP00000148722.1, ENSDART00000184682.1
      Conserved Domains (6) summary
      PHA02896
      Location:140 → 296
      PHA02896; A-type inclusion like protein; Provisional
      smart00072
      Location:753 → 931
      GuKc; Guanylate kinase homologues
      cd00992
      Location:36 → 121
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00625
      Location:782 → 930
      Guanylate_kin; Guanylate kinase
      pfam08648
      Location:183 → 279
      DUF1777; Protein of unknown function (DUF1777)
      cl17036
      Location:654 → 719
      SH3; Src Homology 3 domain superfamily
    Nucleotide Protein Strain
    Heading Accession and Version

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