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    ppp5c protein phosphatase 5, catalytic subunit [ Danio rerio (zebrafish) ]

    Gene ID: 541536, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ppp5cprovided by ZNC
    Official Full Name
    protein phosphatase 5, catalytic subunitprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-050327-75
    See related
    Ensembl:ENSDARG00000034313 AllianceGenome:ZFIN:ZDB-GENE-050327-75
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    fc83f08; im:7146608; wu:fc83f08; zgc:110801
    Summary
    Predicted to enable protein serine/threonine phosphatase activity. Predicted to be active in cytosol and nucleus. Orthologous to human PPP5C (protein phosphatase 5 catalytic subunit). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See ppp5c in Genome Data Viewer
    Location:
    chromosome: 15
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 15 NC_007126.7 (2727939..2753997, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 15 NC_007126.6 (2764370..2790736, complement)

    Chromosome 15 - NC_007126.7Genomic Context describing neighboring genes Neighboring gene claudin-3-like Neighboring gene si:ch211-235m3.5 Neighboring gene transforming growth factor, beta 1a Neighboring gene angiomotin like 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Nongenomic effects and mechanistic study of butyl benzyl phthalate-induced thyroid disruption: Based on integrated in vitro, in silico assays and proteome analysis. Li J, et al. Sci Total Environ, 2022 Aug 25. PMID 35525365
    2. Proteome dynamics in neutrophils of adult zebrafish upon chemically-induced inflammation. Singh SK, et al. Fish Shellfish Immunol, 2014 Sep. PMID 25014315
    3. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
    4. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables myosin phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    serine/threonine-protein phosphatase 5
    NP_001014372.2
    XP_005157433.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001014350.2 → NP_001014372.2  serine/threonine-protein phosphatase 5

      See identical proteins and their annotated locations for NP_001014372.2

      Status: PROVISIONAL

      Source sequence(s)
      BC129287
      UniProtKB/TrEMBL
      A2VD35
      Conserved Domains (6) summary
      smart00156
      Location:186 → 462
      PP2Ac; Protein phosphatase 2A homologues, catalytic domain
      sd00006
      Location:10 → 38
      TPR; TPR repeat [structural motif]
      cd15830
      Location:9 → 141
      BamD; BamD lipoprotein, a component of the beta-barrel assembly machinery
      cd07417
      Location:158 → 473
      MPP_PP5_C; PP5, C-terminal metallophosphatase domain
      pfam13371
      Location:54 → 116
      TPR_9; Tetratricopeptide repeat
      pfam13414
      Location:9 → 75
      TPR_11; TPR repeat

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007126.7 Reference GRCz11 Primary Assembly

      Range
      2727939..2753997 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005157376.5 → XP_005157433.1  serine/threonine-protein phosphatase 5 isoform X1

      UniProtKB/TrEMBL
      A0A8M2B3I0, F6NMN3
      Related
      ENSDARP00000106662.2, ENSDART00000129380.2
      Conserved Domains (6) summary
      smart00156
      Location:194 → 470
      PP2Ac; Protein phosphatase 2A homologues, catalytic domain
      sd00006
      Location:18 → 46
      TPR; TPR repeat [structural motif]
      cd15830
      Location:17 → 149
      BamD; BamD lipoprotein, a component of the beta-barrel assembly machinery
      cd07417
      Location:166 → 481
      MPP_PP5_C; PP5, C-terminal metallophosphatase domain
      pfam13371
      Location:62 → 124
      TPR_9; Tetratricopeptide repeat
      pfam13414
      Location:17 → 83
      TPR_11; TPR repeat
    Nucleotide Protein Strain
    Heading Accession and Version

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