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    ttll1 tubulin tyrosine ligase-like family, member 1 [ Danio rerio (zebrafish) ]

    Gene ID: 393994, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ttll1provided by ZNC
    Official Full Name
    tubulin tyrosine ligase-like family, member 1provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040426-1326
    See related
    Ensembl:ENSDARG00000090778 AllianceGenome:ZFIN:ZDB-GENE-040426-1326
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:63993
    Summary
    Predicted to enable tubulin binding activity and tubulin-glutamic acid ligase activity. Predicted to be involved in sperm axoneme assembly. Predicted to act upstream of or within protein modification process. Predicted to be located in cilium; cytoplasm; and microtubule. Predicted to be active in ciliary basal body. Orthologous to human TTLL1 (TTL family tubulin polyglutamylase complex subunit L1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See ttll1 in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 4 NC_007115.7 (77919953..77932571)
    105 previous assembly GRCz10 (GCF_000002035.5) 4 NC_007115.6 (76535264..76547869)

    Chromosome 4 - NC_007115.7Genomic Context describing neighboring genes Neighboring gene NLR family CARD domain-containing protein 3-like Neighboring gene uncharacterized LOC137491387 Neighboring gene si:zfos-2131b9.2 Neighboring gene protein kinase C and casein kinase substrate in neurons 2 Neighboring gene ADP-ribosylation factor GTPase activating protein 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Chromosome segregation fidelity requires microtubule polyglutamylation by the cancer downregulated enzyme TTLL11. Zadra I, et al. Nat Commun, 2022 Nov 21. PMID 36414642, Free PMC Article
    2. Tubulin tyrosine ligase-like genes ttll3 and ttll6 maintain zebrafish cilia structure and motility. Pathak N, et al. J Biol Chem, 2011 Apr 1. PMID 21262966, Free PMC Article
    3. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Clone Names

    • MGC63993

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables tubulin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables tubulin-glutamic acid ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within protein modification process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in sperm axoneme assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in ciliary basal body IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cilium IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in microtubule IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    polyglutamylase complex subunit TTLL1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001320519.1 → NP_001307448.1  polyglutamylase complex subunit TTLL1

      Status: VALIDATED

      Source sequence(s)
      CU695158
      UniProtKB/TrEMBL
      A0A8M1P2G8, F8W385
      Related
      ENSDARP00000124463.1, ENSDART00000150171.3
      Conserved Domains (1) summary
      pfam03133
      Location:59 → 365
      TTL; Tubulin-tyrosine ligase family

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007115.7 Reference GRCz11 Primary Assembly

      Range
      77919953..77932571
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017354981.3 → XP_017210470.1  polyglutamylase complex subunit TTLL1 isoform X1

      UniProtKB/TrEMBL
      A0A8M1P2G8, F8W385
      Conserved Domains (1) summary
      pfam03133
      Location:59 → 365
      TTL; Tubulin-tyrosine ligase family

    2. XM_017354980.3 → XP_017210469.1  polyglutamylase complex subunit TTLL1 isoform X1

      UniProtKB/TrEMBL
      A0A8M1P2G8, F8W385
      Conserved Domains (1) summary
      pfam03133
      Location:59 → 365
      TTL; Tubulin-tyrosine ligase family

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_201019.1: Suppressed sequence

      Description
      NM_201019.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein
    Heading Accession and Version

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