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    lbr lamin B receptor [ Danio rerio (zebrafish) ]

    Gene ID: 368360, updated on 9-Dec-2024

    Summary

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    Official Symbol
    lbrprovided by ZNC
    Official Full Name
    lamin B receptorprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030804-11
    See related
    Ensembl:ENSDARG00000014013 AllianceGenome:ZFIN:ZDB-GENE-030804-11
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    sb:cb406; zgc:86649; wu:fb75h08; wu:fc47b04; wu:fd36b07
    Summary
    Predicted to enable delta14-sterol reductase activity. Acts upstream of or within cell migration involved in gastrulation. Located in nuclear inner membrane. Is expressed in several structures, including hypochord; nervous system; neural plate; optic vesicle; and tail bud. Human ortholog(s) of this gene implicated in Greenberg dysplasia; Pelger-Huet anomaly; and primary biliary cholangitis. Orthologous to human LBR (lamin B receptor). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See lbr in Genome Data Viewer
    Location:
    chromosome: 20
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 20 NC_007131.7 (36395663..36416890, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 20 NC_007131.6 (36493387..36514011, complement)

    Chromosome 20 - NC_007131.7Genomic Context describing neighboring genes Neighboring gene cornichon family AMPA receptor auxiliary protein 3 Neighboring gene si:dkey-1j5.4 Neighboring gene ENAH actin regulator Neighboring gene golgin subfamily A member 6-like protein 25 Neighboring gene golgin subfamily A member 6-like protein 25

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Transient, flexible gene editing in zebrafish neutrophils and macrophages for determination of cell-autonomous functions. Isiaku AI, et al. Dis Model Mech, 2021 Jul 1. PMID 34296745, Free PMC Article
    2. Structural and functional characterization of the zebrafish lamin B receptor. Schild-Prüfert K, et al. Eur J Cell Biol, 2006 Aug. PMID 16759737
    3. Effects of maternal cadmium exposure on female reproductive functions, gamete quality, and offspring development in zebrafish (Danio rerio). Wu SM, et al. Arch Environ Contam Toxicol, 2013 Oct. PMID 23644582
    4. Expression of myelin transcription factor 1 and lamin B receptor mediate neural progenitor fate transition in the zebrafish spinal cord pMN domain. Xing L, et al. J Biol Chem, 2022 Oct. PMID 36063998, Free PMC Article
    5. Activating transcription factor 3 coordinates differentiation of cardiac and hematopoietic progenitors by regulating glucose metabolism. Yin HM, et al. Sci Adv, 2020 May. PMID 32494702, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Expression of myelin transcription factor 1 and lamin B receptor mediate neural progenitor fate transition in the zebrafish spinal cord pMN domain.
      Title: Expression of myelin transcription factor 1 and lamin B receptor mediate neural progenitor fate transition in the zebrafish spinal cord pMN domain.
    2. Data indicate that the LBR of zebrafish and mammals are both required for correct development of embryos.
      Title: Structural and functional characterization of the zebrafish lamin B receptor.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables delta14-sterol reductase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables delta14-sterol reductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within cell migration involved in gastrulation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cholesterol biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within cholesterol biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cholesterol biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within cholesterol metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within steroid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within steroid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within sterol biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nuclear inner membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nuclear inner membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    delta(14)-sterol reductase LBR
    NP_001002720.1
    XP_021324046.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001002720.1 → NP_001002720.1  delta(14)-sterol reductase LBR

      See identical proteins and their annotated locations for NP_001002720.1

      Status: PROVISIONAL

      Source sequence(s)
      BC075756
      UniProtKB/TrEMBL
      Q6DI34
      Related
      ENSDARP00000015055.6, ENSDART00000019145.8
      Conserved Domains (2) summary
      pfam09465
      Location:1 → 55
      LBR_tudor; Lamin-B receptor of TUDOR domain
      cl21511
      Location:206 → 619
      PEMT; Phospholipid methyltransferase

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007131.7 Reference GRCz11 Primary Assembly

      Range
      36395663..36416890 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021468371.2 → XP_021324046.1  delta(14)-sterol reductase LBR isoform X1

      UniProtKB/TrEMBL
      A0A8M9PP65
      Related
      ENSDARP00000070893.5, ENSDART00000076419.5
      Conserved Domains (2) summary
      pfam09465
      Location:1 → 55
      LBR_tudor; Lamin-B receptor of TUDOR domain
      cl21511
      Location:206 → 619
      PEMT; Phospholipid methyltransferase
    Nucleotide Protein Strain
    Heading Accession and Version

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