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    evlb Enah/Vasp-like b [ Danio rerio (zebrafish) ]

    Gene ID: 402929, updated on 9-Dec-2024

    Summary

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    Official Symbol
    evlbprovided by ZNC
    Official Full Name
    Enah/Vasp-like bprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040426-1804
    See related
    Ensembl:ENSDARG00000099720 AllianceGenome:ZFIN:ZDB-GENE-040426-1804
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:77220
    Summary
    Predicted to enable profilin binding activity. Predicted to be involved in actin polymerization or depolymerization; axon guidance; and positive regulation of actin filament polymerization. Predicted to act upstream of or within protein homotetramerization. Predicted to be located in cell projection; cytoplasm; and stress fiber. Predicted to be active in focal adhesion and plasma membrane. Is expressed in nervous system and trigeminal placode. Orthologous to human EVL (Enah/Vasp-like). [provided by Alliance of Genome Resources, Dec 2024]
    Annotation information
    Annotation category: partial on reference assembly
    Orthologs
    all
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    Genomic context

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    See evlb in Genome Data Viewer
    Location:
    chromosome: 20
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 20 NC_007131.7 (54436233..54480405, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 20 NC_007131.6 (54647017..54876900, complement)

    Chromosome 20 - NC_007131.7Genomic Context describing neighboring genes Neighboring gene leucine rich repeat and fibronectin type III domain containing 5b Neighboring gene YY1 transcription factor b Neighboring gene uncharacterized LOC103909376 Neighboring gene enhancer of split m7 protein-like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Xirp proteins mark injured skeletal muscle in zebrafish. Otten C, et al. PLoS One, 2012. PMID 22355335, Free PMC Article
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
    4. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC77220

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables SH3 domain binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables actin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within actin polymerization or depolymerization IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within protein homotetramerization IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in stress fiber IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Enah/Vasp-like b; enah/Vasp-like b

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_205633.1 → NP_991196.1  Enah/Vasp-like b

      See identical proteins and their annotated locations for NP_991196.1

      Status: PROVISIONAL

      Source sequence(s)
      BC065327
      UniProtKB/TrEMBL
      Q6P120
      Related
      ENSDARP00000132876.2, ENSDART00000171769.2
      Conserved Domains (2) summary
      cd01207
      Location:5 → 113
      EVH1_Ena_VASP-like; Enabled/VASP family EVH1 domain
      pfam08776
      Location:339 → 372
      VASP_tetra; VASP tetramerization domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007131.7 Reference GRCz11 Primary Assembly

      Range
      54436233..54480405 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021468384.2 → XP_021324059.1  enah/Vasp-like b isoform X1

      UniProtKB/TrEMBL
      A0A8M9PH72
      Conserved Domains (2) summary
      cd01207
      Location:31 → 139
      EVH1_Ena_VASP-like; Enabled/VASP family EVH1 domain
      pfam08776
      Location:366 → 400
      VASP_tetra; VASP tetramerisation domain
    Nucleotide Protein Strain
    Heading Accession and Version

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