il13ra2 interleukin 13 receptor, alpha 2 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: il13ra2provided by ZNC
Official Full Name: interleukin 13 receptor, alpha 2provided by ZNC
Primary source: ZFIN:ZDB-GENE-030521-10
See related: Ensembl:ENSDARG00000039436 AllianceGenome:ZFIN:ZDB-GENE-030521-10
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: il-13ra2; sb:cb602; si:dkeyp-110c7.6
Summary: Predicted to enable cytokine binding activity and cytokine receptor activity. Predicted to be involved in cytokine-mediated signaling pathway and positive regulation of cell population proliferation. Predicted to be located in membrane. Predicted to be part of receptor complex. Predicted to be active in external side of plasma membrane. Is expressed in artery; cardiovascular system; otic vesicle; and vein. Human ortholog(s) of this gene implicated in breast cancer and pancreatic cancer. Orthologous to human IL13RA2 (interleukin 13 receptor subunit alpha 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 5

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	5	NC_007116.7 (37101406..37117817, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	5	NC_007116.6 (36501909..36516093, complement)

Chromosome 5 - NC_007116.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

These results indicate that conserved IL-2Rgammac signaling via JAK3 plays a key role during early zebrafish lymphopoiesis, which can be potentially targeted to generate a zebrafish model of human Severe Combined Immunodeficiency.
Title: Conserved IL-2Rγc Signaling Mediates Lymphopoiesis in Zebrafish.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables cytokine binding	IBA Inferred from Biological aspect of Ancestor more info
enables cytokine receptor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in cytokine-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of cell population proliferation	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in external side of plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info
part_of receptor complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: interleukin-13 receptor subunit alpha-2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.