hsd17b3 hydroxysteroid (17-beta) dehydrogenase 3 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: hsd17b3provided by ZNC
Official Full Name: hydroxysteroid (17-beta) dehydrogenase 3provided by ZNC
Primary source: ZFIN:ZDB-GENE-040426-1339
See related: Ensembl:ENSDARG00000023287 AllianceGenome:ZFIN:ZDB-GENE-040426-1339
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zgc:64019
Summary: Enables testosterone 17-beta-dehydrogenase (NADP+) activity. Acts upstream of or within androgen biosynthetic process. Located in endoplasmic reticulum. Is expressed in digestive system; heart; integument; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in 17-beta hydroxysteroid dehydrogenase 3 deficiency and disorder of sexual development. Orthologous to human HSD17B3 (hydroxysteroid 17-beta dehydrogenase 3). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 8

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	8	NC_007119.7 (29855979..29876413)
105	previous assembly	GRCz10 (GCF_000002035.5)	8	NC_007119.6 (29842620..29867181)

Chromosome 8 - NC_007119.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Results suggest that 17beta-hydroxysteroid dehydrogenase (17beta-HSD) type 3 might play slightly different roles in zebrafish compared with human although testosterone itself is likely to have similar functions in both organisms.
Title: Androgen metabolism via 17beta-hydroxysteroid dehydrogenase type 3 in mammalian and non-mammalian vertebrates: comparison of the human and the zebrafish enzyme.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables testosterone 17-beta-dehydrogenase (NADP+) activity	IBA Inferred from Biological aspect of Ancestor more info
enables testosterone 17-beta-dehydrogenase (NADP+) activity	IDA Inferred from Direct Assay more info	PubMed
enables testosterone 17-beta-dehydrogenase (NADP+) activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within androgen biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within lipid metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within steroid biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in testosterone biosynthetic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: 17-beta-hydroxysteroid dehydrogenase type 3

Names: 17-beta-HSD 3; short chain dehydrogenase/reductase family 12C member 2; testicular 17-beta-hydroxysteroid dehydrogenase; testosterone 17-beta-dehydrogenase 3

NP_956658.1

EC 1.1.1.64

XP_005167205.1

EC 1.1.1.64

XP_068078997.1

EC 1.1.1.64

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_200364.1 → NP_956658.1 17-beta-hydroxysteroid dehydrogenase type 3

See identical proteins and their annotated locations for NP_956658.1

Status: PROVISIONAL

Source sequence(s)

BC053203

UniProtKB/TrEMBL

B2GTK0, F8W2R2, Q7T396

Related

ENSDARP00000061980.6, ENSDART00000061981.8

Conserved Domains (1) summary

cd05356
Location:1 → 216

17beta-HSD1_like_SDR_c; 17-beta-hydroxysteroid dehydrogenases (17beta-HSDs) types -1, -3, and -12, -like, classical (c) SDRs

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007119.7 Reference GRCz11 Primary Assembly

Range

29855979..29876413

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005167148.5 → XP_005167205.1 17-beta-hydroxysteroid dehydrogenase type 3 isoform X1

See identical proteins and their annotated locations for XP_005167205.1

UniProtKB/Swiss-Prot

Q6QA32

Conserved Domains (1) summary

cd05356
Location:47 → 287

17beta-HSD1_like_SDR_c; 17-beta-hydroxysteroid dehydrogenases (17beta-HSDs) types -1, -3, and -12, -like, classical (c) SDRs
XM_068222896.1 → XP_068078997.1 17-beta-hydroxysteroid dehydrogenase type 3 isoform X2