U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    dtx3 deltex E3 ubiquitin ligase 3 [ Danio rerio (zebrafish) ]

    Gene ID: 393500, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    dtx3provided by ZNC
    Official Full Name
    deltex E3 ubiquitin ligase 3provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040426-1640
    See related
    Ensembl:ENSDARG00000025766 AllianceGenome:ZFIN:ZDB-GENE-040426-1640
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    deltex3; fi25g12; zgc:66440; wu:fi25g12
    Summary
    Predicted to enable metal ion binding activity and ubiquitin protein ligase activity. Predicted to be involved in protein ubiquitination. Predicted to act upstream of or within Notch signaling pathway. Predicted to be located in cytoplasm. Orthologous to human DTX3 (deltex E3 ubiquitin ligase 3). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See dtx3 in Genome Data Viewer
    Location:
    chromosome: 23
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 23 NC_007134.7 (27040128..27050084, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 23 NC_007134.6 (27113587..27134526, complement)

    Chromosome 23 - NC_007134.7Genomic Context describing neighboring genes Neighboring gene calcium channel, voltage-dependent, beta 3b Neighboring gene Rho family GTPase 1b Neighboring gene prostaglandin E synthase 3a (cytosolic) Neighboring gene major intrinsic protein of lens fiber a

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. A comparative study of the expression patterns of Fign family members in zebrafish embryonic development. Dong Z, et al. Comp Biochem Physiol B Biochem Mol Biol, 2021 Jan. PMID 33069857
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Clone Names

    • MGC66440

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin protein ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in Notch signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within Notch signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    probable E3 ubiquitin-protein ligase DTX3
    NP_956822.3
    XP_005162299.1
    XP_005162301.1
    XP_009295112.1
    XP_068072809.1

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_200528.3 → NP_956822.3  probable E3 ubiquitin-protein ligase DTX3

      Status: VALIDATED

      Source sequence(s)
      CR354433
      UniProtKB/TrEMBL
      A0A8M3AVB3, F1QUJ1
      Related
      ENSDARP00000110688.2, ENSDART00000128718.3

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007134.7 Reference GRCz11 Primary Assembly

      Range
      27040128..27050084 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005162242.5 → XP_005162299.1  probable E3 ubiquitin-protein ligase DTX3 isoform X1

      See identical proteins and their annotated locations for XP_005162299.1

      UniProtKB/TrEMBL
      A0A8M2B9F2
      Conserved Domains (2) summary
      cd09633
      Location:233 → 365
      Deltex_C; Domain found at the C-terminus of deltex-like
      cd00162
      Location:186 → 225
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...

    2. XM_009296837.4 → XP_009295112.1  probable E3 ubiquitin-protein ligase DTX3 isoform X1

      See identical proteins and their annotated locations for XP_009295112.1

      UniProtKB/TrEMBL
      A0A8M2B9F2
      Conserved Domains (2) summary
      cd09633
      Location:233 → 365
      Deltex_C; Domain found at the C-terminus of deltex-like
      cd00162
      Location:186 → 225
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...

    3. XM_068216708.1 → XP_068072809.1  probable E3 ubiquitin-protein ligase DTX3 isoform X2

      UniProtKB/TrEMBL
      A0A2R8Q098, A0A2R8QRQ2, A0A8M3B638, F1R959, Q4G0B5

    4. XM_005162244.4 → XP_005162301.1  probable E3 ubiquitin-protein ligase DTX3 isoform X2

      See identical proteins and their annotated locations for XP_005162301.1

      UniProtKB/TrEMBL
      A0A2R8Q098, A0A2R8QRQ2, A0A8M3B638, F1R959, Q4G0B5
      Related
      ENSDARP00000107053.2, ENSDART00000124482.4
      Conserved Domains (2) summary
      cd09633
      Location:224 → 356
      Deltex_C; Domain found at the C-terminus of deltex-like
      cd00162
      Location:177 → 216
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018395154.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      281548..290021 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Tools