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    macroh2a2 macroH2A.2 histone [ Danio rerio (zebrafish) ]

    Gene ID: 558711, updated on 9-Dec-2024

    Summary

    Official Symbol
    macroh2a2provided by ZNC
    Official Full Name
    macroH2A.2 histoneprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-050913-114
    See related
    Ensembl:ENSDARG00000087897 AllianceGenome:ZFIN:ZDB-GENE-050913-114
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    h2afy2; im:6898017; wu:fa14g05; zgc:114051
    Summary
    Enables transcription cis-regulatory region binding activity. Involved in brain development. Predicted to be located in chromosome. Predicted to be part of nucleosome. Predicted to be active in nucleus. Is expressed in brain; central nervous system; retina; and retinal ganglion cell layer. Orthologous to human MACROH2A2 (macroH2A.2 histone). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

    See macroh2a2 in Genome Data Viewer
    Location:
    chromosome: 13
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 13 NC_007124.7 (7753049..7767594, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 13 NC_007124.6 (7420847..7435392, complement)

    Chromosome 13 - NC_007124.7Genomic Context describing neighboring genes Neighboring gene paired-like homeodomain 3 Neighboring gene golgi brefeldin A resistant guanine nucleotide exchange factor 1 Neighboring gene uncharacterized LOC137487364 Neighboring gene collagen, type XIII, alpha 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    General gene information

    Markers

    Clone Names

    • MGC114051

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein heterodimerization activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables structural constituent of chromatin IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables structural constituent of chromatin IEA
    Inferred from Electronic Annotation
    more info
     
    enables transcription cis-regulatory region binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in brain development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within chromatin organization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in heterochromatin formation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in negative regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in negative regulation of transcription of nucleolar large rRNA by RNA polymerase I IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within nucleosome assembly IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in nucleosome assembly IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
     
    part_of nucleosome IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of nucleosome IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    core histone macro-H2A.2
    Names
    H2A histone family, member Y2
    H2A2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001025502.1NP_001020673.1  core histone macro-H2A.2

      See identical proteins and their annotated locations for NP_001020673.1

      Status: PROVISIONAL

      Source sequence(s)
      BC097115
      UniProtKB/TrEMBL
      A0A8M3BEG6, Q4V914
      Related
      ENSDARP00000105230.1, ENSDART00000121952.3
      Conserved Domains (3) summary
      smart00414
      Location:14119
      H2A; Histone 2A
      cd00074
      Location:5117
      H2A; Histone 2A; H2A is a subunit of the nucleosome. The nucleosome is an octamer containing two H2A, H2B, H3, and H4 subunits. The H2A subunit performs essential roles in maintaining structural integrity of the nucleosome, chromatin condensation, and binding ...
      cd02904
      Location:173359
      Macro_H2A_like; Macro domain, Macro_H2A_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose ...

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007124.7 Reference GRCz11 Primary Assembly

      Range
      7753049..7767594 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_009307097.2XP_009305372.1  core histone macro-H2A.2 isoform X1

      See identical proteins and their annotated locations for XP_009305372.1

      UniProtKB/TrEMBL
      A0A8M3BEG6, Q4V914
      Conserved Domains (3) summary
      smart00414
      Location:14119
      H2A; Histone 2A
      cd00074
      Location:5117
      H2A; Histone 2A; H2A is a subunit of the nucleosome. The nucleosome is an octamer containing two H2A, H2B, H3, and H4 subunits. The H2A subunit performs essential roles in maintaining structural integrity of the nucleosome, chromatin condensation, and binding ...
      cd02904
      Location:173359
      Macro_H2A_like; Macro domain, Macro_H2A_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose ...