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    zp3b zona pellucida glycoprotein 3b [ Danio rerio (zebrafish) ]

    Gene ID: 64692, updated on 9-Dec-2024

    Summary

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    Official Symbol
    zp3bprovided by ZNC
    Official Full Name
    zona pellucida glycoprotein 3bprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-031124-2
    See related
    Ensembl:ENSDARG00000039828 AllianceGenome:ZFIN:ZDB-GENE-031124-2
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    ZP3; ZPC; zpc6; zfZPC; fa55e05; wu:fa55e05
    Summary
    Predicted to enable acrosin binding activity. Predicted to be involved in binding activity of sperm to zona pellucida; egg coat formation; and positive regulation of acrosome reaction. Predicted to be located in egg coat; extracellular region; and plasma membrane. Predicted to be active in extracellular matrix. Orthologous to human ZP3 (zona pellucida glycoprotein 3). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See zp3b in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 2 NC_007113.7 (6253291..6258794)
    105 previous assembly GRCz10 (GCF_000002035.5) 2 NC_007113.6 (6341409..6346912)

    Chromosome 2 - NC_007113.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC137487427 Neighboring gene guanine nucleotide binding protein (G protein), gamma 5 Neighboring gene ADP-ribosylation factor-like 14 Neighboring gene protein phosphatase, Mg2+/Mn2+ dependent, 1La

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Identification and spatial distribution of the mRNA encoding an egg envelope component of the Cyprinid zebrafish, Danio rerio, homologous to the mammalian ZP3 (ZPC). Del Giacco L, et al. Dev Genes Evol, 2000 Jan. PMID 10603086
    2. Dynamic microtubules at the vegetal cortex predict the embryonic axis in zebrafish. Tran LD, et al. Development, 2012 Oct. PMID 22949618
    3. Whole embryo chromatin immunoprecipitation protocol for the in vivo study of zebrafish development. Havis E, et al. Biotechniques, 2006 Jan. PMID 16454037
    4. The Hippo pathway effector Taz is required for cell morphogenesis and fertilization in zebrafish. Dingare C, et al. Development, 2018 Nov 22. PMID 30327325, Free PMC Article
    5. Rapid generation of maternal mutants via oocyte transgenic expression of CRISPR-Cas9 and sgRNAs in zebrafish. Zhang C, et al. Sci Adv, 2021 Aug. PMID 34362733, Free PMC Article

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables acrosin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables structural constituent of egg coat IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in binding of sperm to zona pellucida IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in egg coat formation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of acrosome reaction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in egg coat IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in extracellular matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    zona pellucida sperm-binding protein 3b
    Names
    chorion proteic component

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_131696.1 → NP_571771.1  zona pellucida sperm-binding protein 3b precursor

      See identical proteins and their annotated locations for NP_571771.1

      Status: PROVISIONAL

      Source sequence(s)
      U55863
      UniProtKB/TrEMBL
      O12989
      Related
      ENSDARP00000058255.4, ENSDART00000058256.6
      Conserved Domains (2) summary
      smart00241
      Location:98 → 355
      ZP; Zona pellucida (ZP) domain
      pfam00100
      Location:219 → 354
      Zona_pellucida; Zona pellucida-like domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007113.7 Reference GRCz11 Primary Assembly

      Range
      6253291..6258794
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version

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