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    rpl27 ribosomal protein L27 [ Danio rerio (zebrafish) ]

    Gene ID: 325618, updated on 9-Dec-2024

    Summary

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    Official Symbol
    rpl27provided by ZNC
    Official Full Name
    ribosomal protein L27provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-4343
    See related
    Ensembl:ENSDARG00000015128 AllianceGenome:ZFIN:ZDB-GENE-030131-4343
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    fc93a08; zgc:56171; wu:fc93a08
    Summary
    Predicted to be a structural constituent of ribosome. Acts upstream of or within erythrocyte differentiation. Predicted to be located in cytoplasmic side of rough endoplasmic reticulum membrane. Predicted to be part of cytosolic large ribosomal subunit. Is expressed in endodermal cell; intestine; liver; and pancreas. Human ortholog(s) of this gene implicated in Diamond-Blackfan anemia 16. Orthologous to human RPL27 (ribosomal protein L27). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See rpl27 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 3 NC_007114.7 (29893966..29899226, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 3 NC_007114.6 (29763124..29768384, complement)

    Chromosome 3 - NC_007114.7Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA U83B Neighboring gene ribosomal protein L3 Neighboring gene solute carrier family 25 member 39 Neighboring gene RUN domain containing 1 Neighboring gene granulin a antisense Neighboring gene granulin a

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Loss of function mutations in RPL27 and RPS27 identified by whole-exome sequencing in Diamond-Blackfan anaemia. Wang R, et al. Br J Haematol, 2015 Mar. PMID 25424902
    2. Systematic identification of seven ribosomal protein genes in bighead carp and their expression in response to microcystin-LR. Cai Y, et al. J Toxicol Sci, 2016 Apr. PMID 26961614
    3. Chemical and biological transfer: Which one is responsible for the maternal transfer toxicity of tris(1,3-dichloro-2-propyl) phosphate in zebrafish? Zhang Y, et al. Environ Pollut, 2018 Dec. PMID 30273864
    4. Multiple ribosomal proteins are expressed at high levels in developing zebrafish endoderm and are required for normal exocrine pancreas development. Provost E, et al. Zebrafish, 2013 Jun. PMID 23697888, Free PMC Article
    5. First profiling of lysine crotonylation of myofilament proteins and ribosomal proteins in zebrafish embryos. Kwon OK, et al. Sci Rep, 2018 Feb 26. PMID 29483630, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables structural constituent of ribosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables structural constituent of ribosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within erythrocyte differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasmic side of rough endoplasmic reticulum membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of cytosolic large ribosomal subunit IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of large ribosomal subunit ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of ribonucleoprotein complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in ribosome IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    large ribosomal subunit protein eL27
    Names
    60S ribosomal protein L27
    NP_956018.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_199724.1 → NP_956018.1  large ribosomal subunit protein eL27

      See identical proteins and their annotated locations for NP_956018.1

      Status: PROVISIONAL

      Source sequence(s)
      BC045965
      UniProtKB/Swiss-Prot
      Q7ZV82
      UniProtKB/TrEMBL
      B2GP62
      Related
      ENSDARP00000018737.6, ENSDART00000020311.7
      Conserved Domains (2) summary
      COG2163
      Location:1 → 127
      RPL14A; Ribosomal protein L14E/L6E/L27E [Translation, ribosomal structure and biogenesis]
      cl00354
      Location:1 → 136
      KOW; KOW: an acronym for the authors' surnames (Kyrpides, Ouzounis and Woese)

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007114.7 Reference GRCz11 Primary Assembly

      Range
      29893966..29899226 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7ZV82.3 GenPept UniProtKB/Swiss-Prot:Q7ZV82

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.