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    zgc:136930 zgc:136930 [ Danio rerio (zebrafish) ]

    Gene ID: 563946, updated on 9-Dec-2024

    Summary

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    Official Symbol
    zgc:136930provided by ZNC
    Official Full Name
    zgc:136930provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-060312-16
    See related
    Ensembl:ENSDARG00000055192 AllianceGenome:ZFIN:ZDB-GENE-060312-16
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    fj22d03; wu:fj22d03
    Summary
    Predicted to be a structural constituent of skin epidermis. Predicted to be involved in intermediate filament organization and keratinization. Predicted to be located in intermediate filament. Predicted to be active in keratin filament. Human ortholog(s) of this gene implicated in breast cancer; ectodermal dysplasia 4; erythrokeratodermia variabilis et progressiva 5; hair disease; and monilethrix. Orthologous to several human genes including KRT78 (keratin 78); KRT80 (keratin 80); and KRT81 (keratin 81). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See zgc:136930 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 2 NC_007113.7 (32780124..32790888)
    105 previous assembly GRCz10 (GCF_000002035.5) 2 NC_007113.6 (32796920..32807669)

    Chromosome 2 - NC_007113.7Genomic Context describing neighboring genes Neighboring gene chemokine (C-C motif) receptor 9a Neighboring gene kelch-like family member 18 Neighboring gene beaded filament structural protein 2, phakinin Neighboring gene uncharacterized LOC110438072 Neighboring gene pre-mRNA processing factor 4Ba

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Genes coding for intermediate filament proteins closely related to the hagfish "thread keratins (TK)" alpha and gamma also exist in lamprey, teleosts and amphibians. Schaffeld M, et al. Exp Cell Res, 2006 May 15. PMID 16494865
    2. UVB Irradiation Induced Cell Damage and Early Onset of Junbb Expression in Zebrafish. Chen RY, et al. Animals (Basel), 2020 Jun 25. PMID 32630437, Free PMC Article
    3. Tissue-Specific Transcriptomes Reveal Gene Expression Trajectories in Two Maturing Skin Epithelial Layers in Zebrafish Embryos. Cokus SJ, et al. G3 (Bethesda), 2019 Oct 7. PMID 31431477, Free PMC Article
    4. Stable isotope labeling in zebrafish allows in vivo monitoring of cardiac morphogenesis. Konzer A, et al. Mol Cell Proteomics, 2013 Jun. PMID 23412571, Free PMC Article
    5. Transcriptomic, proteomic, and metabolomic landscape of positional memory in the caudal fin of zebrafish. Rabinowitz JS, et al. Proc Natl Acad Sci U S A, 2017 Jan 31. PMID 28096348, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC136930

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    located_in intermediate filament IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein LOC563946
    Names
    thread keratin gamma

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001039819.2 → NP_001034908.1  uncharacterized protein LOC563946

      See identical proteins and their annotated locations for NP_001034908.1

      Status: VALIDATED

      Source sequence(s)
      CR855308
      UniProtKB/TrEMBL
      Q29R96
      Related
      ENSDARP00000076687.4, ENSDART00000082250.5
      Conserved Domains (1) summary
      pfam00038
      Location:34 → 353
      Filament; Intermediate filament protein

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007113.7 Reference GRCz11 Primary Assembly

      Range
      32780124..32790888
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021480887.2 → XP_021336562.1  uncharacterized protein LOC563946 isoform X1

      UniProtKB/TrEMBL
      A0A8M9PYS6
      Conserved Domains (1) summary
      pfam00038
      Location:120 → 439
      Filament; Intermediate filament protein
    Nucleotide Protein
    Heading Accession and Version

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