e2f6 E2F transcription factor 6 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: e2f6provided by ZNC
Official Full Name: E2F transcription factor 6provided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-513
See related: Ensembl:ENSDARG00000008119 AllianceGenome:ZFIN:ZDB-GENE-030131-513
Gene type: protein coding
RefSeq status: PREDICTED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: fb34f06; wu:fb34f06; zgc:136607; si:ch211-195d17.2
Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to act upstream of or within regulation of DNA-templated transcription. Predicted to be located in nucleus. Predicted to be part of RNA polymerase II transcription regulator complex. Orthologous to human E2F6 (E2F transcription factor 6). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 20

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	20	NC_007131.7 (29676870..29683784, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	20	NC_007131.6 (29773991..29780935, complement)

Chromosome 20 - NC_007131.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

fb34f06 (e-PCR)
- UniSTS:187095

fb34f06.x1 (e-PCR)
- UniSTS:190443

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein dimerization activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of RNA polymerase II transcription regulator complex	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
part_of transcription regulator complex	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: uncharacterized protein LOC560495

Names: THAP-E2F6 fusion

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001030144.1 → NP_001025315.1 uncharacterized protein LOC560495

Status: PREDICTED

Source sequence(s)

BX255963

UniProtKB/TrEMBL

A0A8M1N779

Related

ENSDARP00000020835.10, ENSDART00000015928.10

Conserved Domains (4) summary

smart00980
Location:3 → 79

THAP; The THAP domain is a putative DNA-binding domain (DBD) and probably also binds a zinc ion

cd14660
Location:263 → 292

E2F_DD; coiled coil [structural motif]

pfam02319
Location:187 → 246

E2F_TDP; E2F/DP family winged-helix DNA-binding domain

pfam16421
Location:263 → 355

E2F_CC-MB; E2F transcription factor CC-MB domain

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007131.7 Reference GRCz11 Primary Assembly

Range

29676870..29683784 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005160725.5 → XP_005160782.1 uncharacterized protein LOC560495 isoform X1

UniProtKB/TrEMBL

A0A8M2B7U6, Q5TZC4

Related

ENSDARP00000121362.2, ENSDART00000131219.4

Conserved Domains (3) summary

cd14660
Location:263 → 358

E2F_DD; Dimerization domain of E2F transcription factors

pfam02319
Location:187 → 246

E2F_TDP; E2F/DP family winged-helix DNA-binding domain

pfam05485
Location:3 → 79

THAP; THAP domain