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    sost sclerostin [ Danio rerio (zebrafish) ]

    Gene ID: 100000500, updated on 9-Dec-2024

    Summary

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    Official Symbol
    sostprovided by ZNC
    Official Full Name
    sclerostinprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-110411-139
    See related
    Ensembl:ENSDARG00000061259 AllianceGenome:ZFIN:ZDB-GENE-110411-139
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    si:dkeyp-44b3.1
    Summary
    Predicted to enable BMP binding activity. Predicted to be involved in negative regulation of BMP signaling pathway; negative regulation of Wnt signaling pathway; and ossification. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in several structures, including Kupffer's vesicle; endochondral bone; nervous system; notochord outer sheath cell; and pharyngeal arch cartilage. Human ortholog(s) of this gene implicated in autosomal dominant craniodiaphyseal dysplasia; sclerosteosis; and sclerosteosis 1. Orthologous to human SOST (sclerostin). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See sost in Genome Data Viewer
    Location:
    chromosome: 12
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 12 NC_007123.7 (27331361..27334329)
    105 previous assembly GRCz10 (GCF_000002035.5) 12 NC_007123.6 (27239968..27244296)

    Chromosome 12 - NC_007123.7Genomic Context describing neighboring genes Neighboring gene ADP-ribosylation factor-like 4D Neighboring gene dual specificity phosphatase 3a Neighboring gene mesenchyme homeobox 1 Neighboring gene ETS variant transcription factor 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Expression of sclerostin in the developing zebrafish (Danio rerio) brain and skeleton. McNulty MS, et al. Gene Expr Patterns, 2012 Aug-Sep. PMID 22575304, Free PMC Article
    2. Distinct progenitor populations mediate regeneration in the zebrafish lateral line. Thomas ED, et al. Elife, 2019 Mar 5. PMID 30834891, Free PMC Article
    3. A novel nonosteocytic regulatory mechanism of bone modeling. Ofer L, et al. PLoS Biol, 2019 Feb. PMID 30707688, Free PMC Article
    4. Anti-osteoporosis effects of Anemarrhenae Rhizoma / Phellodendri Chinensis Cortex herb pair and its major active components in diabetic rats and zebrafish. Xu P, et al. J Ethnopharmacol, 2022 Jul 15. PMID 35398497
    5. Probiotic supplementation promotes calcification in Danio rerio larvae: a molecular study. Maradonna F, et al. PLoS One, 2013. PMID 24358259, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables BMP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables heparin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of BMP signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of Wnt signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ossification IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    sclerostin

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007123.7 Reference GRCz11 Primary Assembly

      Range
      27331361..27334329
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021480342.2 → XP_021336017.1  sclerostin

      UniProtKB/TrEMBL
      A0A8M9PX42, E7EXX7
      Related
      ENSDARP00000081642.5, ENSDART00000087208.6
      Conserved Domains (1) summary
      cl21545
      Location:34 → 208
      GHB_like; Glycoprotein hormone beta chain homologues

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018394847.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      250464..253336
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_001340647.6 → XP_001340683.2  sclerostin

      UniProtKB/TrEMBL
      A0A8M1PZF1
      Conserved Domains (1) summary
      cl21545
      Location:34 → 208
      GHB_like; Glycoprotein hormone beta chain homologues
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

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