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    bicra BRD4 interacting chromatin remodeling complex associated protein [ Danio rerio (zebrafish) ]

    Gene ID: 386775, updated on 27-Dec-2024

    Summary

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    Official Symbol
    bicraprovided by ZNC
    Official Full Name
    BRD4 interacting chromatin remodeling complex associated proteinprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-031116-2
    See related
    Ensembl:ENSDARG00000061159 AllianceGenome:ZFIN:ZDB-GENE-031116-2
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    gltscr1; sb:cb888; wu:fc28g11; si:dkey-224e22.6
    Summary
    Acts upstream of or within embryonic cranial skeleton morphogenesis. Is expressed in several structures, including hindbrain neural plate; intermediate cell mass of mesoderm; midbrain neural keel; nervous system; and presumptive telencephalon. Human ortholog(s) of this gene implicated in Coffin-Siris syndrome 12. Orthologous to human BICRA (BRD4 interacting chromatin remodeling complex associated protein). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See bicra in Genome Data Viewer
    Location:
    chromosome: 18
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 18 NC_007129.7 (44628844..44646968)
    105 previous assembly GRCz10 (GCF_000002035.5) 18 NC_007129.6 (44634296..44653514)

    Chromosome 18 - NC_007129.7Genomic Context describing neighboring genes Neighboring gene sprouty related EVH1 domain containing 3 Neighboring gene proteasome 26S subunit, non-ATPase 8 Neighboring gene EH-domain containing 2b Neighboring gene uncharacterized LOC137488335

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. BICRA, a SWI/SNF Complex Member, Is Associated with BAF-Disorder Related Phenotypes in Humans and Model Organisms. Barish S, et al. Am J Hum Genet, 2020 Dec 3. PMID 33232675, Free PMC Article
    2. Hematopoietic gene expression profile in zebrafish kidney marrow. Song HD, et al. Proc Natl Acad Sci U S A, 2004 Nov 16. PMID 15520368, Free PMC Article
    3. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
    5. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. BICRA, a SWI/SNF Complex Member, Is Associated with BAF-Disorder Related Phenotypes in Humans and Model Organisms.
      Title: BICRA, a SWI/SNF Complex Member, Is Associated with BAF-Disorder Related Phenotypes in Humans and Model Organisms.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Process Evidence Code Pubs
    acts_upstream_of_or_within embryonic cranial skeleton morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    glioma tumor suppressor candidate region gene 1 protein; BRD4-interacting chromatin-remodeling complex-associated protein
    Names
    glioma tumor suppressor candidate region gene 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007129.7 Reference GRCz11 Primary Assembly

      Range
      44628844..44646968
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005159252.5 → XP_005159309.1  BRD4-interacting chromatin-remodeling complex-associated protein isoform X1

      UniProtKB/TrEMBL
      A0A8M2B5V9
      Conserved Domains (1) summary
      pfam15249
      Location:1156 → 1260
      GLTSCR1; Conserved region of unknown function on GLTSCR protein

    2. XM_005159253.5 → XP_005159310.1  BRD4-interacting chromatin-remodeling complex-associated protein isoform X2

      UniProtKB/TrEMBL
      A0A8M2B5S5
      Conserved Domains (1) summary
      pfam15249
      Location:1156 → 1259
      GLTSCR1; Conserved region of unknown function on GLTSCR protein

    3. XM_005159254.5 → XP_005159311.1  BRD4-interacting chromatin-remodeling complex-associated protein isoform X5

      UniProtKB/TrEMBL
      A0A8M2B5S4
      Conserved Domains (1) summary
      pfam15249
      Location:1094 → 1198
      GLTSCR1; Conserved region of unknown function on GLTSCR protein

    4. XM_068214939.1 → XP_068071040.1  BRD4-interacting chromatin-remodeling complex-associated protein isoform X6

    5. XM_001922789.8 → XP_001922824.3  BRD4-interacting chromatin-remodeling complex-associated protein isoform X3

      UniProtKB/TrEMBL
      A0A8M1QHS7
      Conserved Domains (1) summary
      pfam15249
      Location:1134 → 1238
      GLTSCR1; Conserved region of unknown function on GLTSCR protein

    6. XM_068214938.1 → XP_068071039.1  BRD4-interacting chromatin-remodeling complex-associated protein isoform X4

      Related
      ENSDARP00000122886.1, ENSDART00000144271.2

    7. XM_068214940.1 → XP_068071041.1  BRD4-interacting chromatin-remodeling complex-associated protein isoform X7

      Related
      ENSDARP00000089311.4, ENSDART00000098540.4
    Nucleotide Protein
    Heading Accession and Version

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