urod uroporphyrinogen decarboxylase [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: urodprovided by ZNC
Official Full Name: uroporphyrinogen decarboxylaseprovided by ZNC
Primary source: ZFIN:ZDB-GENE-000208-18
See related: Ensembl:ENSDARG00000006818 AllianceGenome:ZFIN:ZDB-GENE-000208-18
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: wu:fc43e09
Summary: Enables uroporphyrinogen decarboxylase activity. Acts upstream of or within porphyrin-containing compound metabolic process. Predicted to be located in cytoplasm. Predicted to be active in cytosol. Is expressed in blood; intermediate cell mass of mesoderm; and presumptive blood. Used to study hepatoerythropoietic porphyria. Human ortholog(s) of this gene implicated in porphyria cutanea tarda. Orthologous to human UROD (uroporphyrinogen decarboxylase). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 2

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	2	NC_007113.7 (27555942..27575699, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	2	NC_007113.6 (27900308..27920065, complement)

Chromosome 2 - NC_007113.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables carboxy-lyase activity	IEA Inferred from Electronic Annotation more info
enables lyase activity	IEA Inferred from Electronic Annotation more info
enables uroporphyrinogen decarboxylase activity	IBA Inferred from Biological aspect of Ancestor more info
enables uroporphyrinogen decarboxylase activity	IDA Inferred from Direct Assay more info	PubMed
enables uroporphyrinogen decarboxylase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in heme biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within heme biosynthetic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within porphyrin-containing compound biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in porphyrin-containing compound catabolic process	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within porphyrin-containing compound metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in protoporphyrinogen IX biosynthetic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: uroporphyrinogen decarboxylase

Names: UPD; URO-D; yqe; yquem

NP_571422.1

EC 4.1.1.37

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_131347.1 → NP_571422.1 uroporphyrinogen decarboxylase

See identical proteins and their annotated locations for NP_571422.1

Status: PROVISIONAL

Source sequence(s)

AF095639

UniProtKB/Swiss-Prot

Q9PTS2

Related

ENSDARP00000023867.5, ENSDART00000014568.7

Conserved Domains (1) summary

cd00717
Location:22 → 361

URO-D; Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction ...