vps36 vacuolar protein sorting 36 homolog [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: vps36provided by ZNC
Official Full Name: vacuolar protein sorting 36 homologprovided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-7753
See related: Ensembl:ENSDARG00000057021 AllianceGenome:ZFIN:ZDB-GENE-030131-7753
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: fj33d07; zgc:55965; wu:fj33d07
Summary: Predicted to enable ubiquitin binding activity. Predicted to be involved in protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway. Predicted to act upstream of or within endosome transport via multivesicular body sorting pathway and protein transport. Predicted to be located in endosome. Predicted to be part of ESCRT II complex. Predicted to be active in late endosome membrane. Orthologous to human VPS36 (vacuolar protein sorting 36 homolog). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 10

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	10	NC_007121.7 (24660171..24677414)
105	previous assembly	GRCz10 (GCF_000002035.5)	10	NC_007121.6 (24690719..24707962)

Chromosome 10 - NC_007121.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables phosphatidylinositol-3-phosphate binding	IEA Inferred from Electronic Annotation more info
enables ubiquitin binding	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within endosome transport via multivesicular body sorting pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within protein transport	IEA Inferred from Electronic Annotation more info
involved_in protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of ESCRT II complex	IBA Inferred from Biological aspect of Ancestor more info
part_of ESCRT II complex	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in endosome	IEA Inferred from Electronic Annotation more info
located_in endosome	ISS Inferred from Sequence or Structural Similarity more info
is_active_in late endosome membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: vacuolar protein-sorting-associated protein 36

Names: ESCRT-II complex subunit VPS36

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_199977.1 → NP_956271.1 vacuolar protein-sorting-associated protein 36

See identical proteins and their annotated locations for NP_956271.1

Status: PROVISIONAL

Source sequence(s)

BC045509

UniProtKB/Swiss-Prot

Q7ZVK4

Related

ENSDARP00000074049.3, ENSDART00000079597.4

Conserved Domains (2) summary

cd13226
Location:1 → 128

PH-GRAM-like_Eap45; Pleckstrin homology-like domain or GLUE (GRAM-like ubiquitin-binding in Eap45) domain of Eap45

pfam04157
Location:155 → 369

EAP30; EAP30/Vps36 family