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    dbi diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein) [ Danio rerio (zebrafish) ]

    Gene ID: 393831, updated on 9-Dec-2024

    Summary

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    Official Symbol
    dbiprovided by ZNC
    Official Full Name
    diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein)provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040426-1861
    See related
    Ensembl:ENSDARG00000026369 AllianceGenome:ZFIN:ZDB-GENE-040426-1861
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:56108; zgc:77734; wu:fb63e10
    Summary
    Predicted to enable fatty-acyl-CoA binding activity. Predicted to be involved in fatty acid metabolic process. Is expressed in gut. Orthologous to human DBI (diazepam binding inhibitor, acyl-CoA binding protein). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See dbi in Genome Data Viewer
    Location:
    chromosome: 9
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 9 NC_007120.7 (907459..914886)
    105 previous assembly GRCz10 (GCF_000002035.5) 9 NC_007120.6 (907950..915377)

    Chromosome 9 - NC_007120.7Genomic Context describing neighboring genes Neighboring gene STEAP family member 3, metalloreductase Neighboring gene zgc:101851 Neighboring gene transmembrane protein 37 Neighboring gene secretin receptor

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Chronic exposure to 6:2 chlorinated polyfluorinated ether sulfonate acid (F-53B) induced hepatotoxic effects in adult zebrafish and disrupted the PPAR signaling pathway in their offspring. Shi G, et al. Environ Pollut, 2019 Jun. PMID 30928526
    2. Transcriptional study of appetite regulating genes in the brain of zebrafish (Danio rerio) with impaired leptin signalling. Ahi EP, et al. Sci Rep, 2019 Dec 27. PMID 31882937, Free PMC Article
    3. Characterization of Intracellular Peptides from Zebrafish (Danio rerio) Brain. Teixeira CMM, et al. Zebrafish, 2019 Jun. PMID 31017557
    4. Appetite regulating genes in zebrafish gut; a gene expression study. Ahi EP, et al. PLoS One, 2022. PMID 35853004, Free PMC Article
    5. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC77734

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables fatty-acyl-CoA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables fatty-acyl-CoA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables lipid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metallocarboxypeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in fatty acid metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    acyl-CoA-binding protein
    NP_001296092.1
    NP_955902.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001309163.1 → NP_001296092.1  acyl-CoA-binding protein isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate terminal exon compared to variant 1. This encoded isoform (2) has a shorter and distinct C-terminus compared to isoform 1.
      Source sequence(s)
      CU463316, EH502497
      UniProtKB/TrEMBL
      A0A8M1P7M5, E9QFI5
      Related
      ENSDARP00000116742.1, ENSDART00000144114.2
      Conserved Domains (1) summary
      pfam00887
      Location:3 → 64
      ACBP; Acyl CoA binding protein

    2. NM_199608.2 → NP_955902.1  acyl-CoA-binding protein isoform 1

      See identical proteins and their annotated locations for NP_955902.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      BC062845, CK028074, EH526038, EH546049
      UniProtKB/TrEMBL
      A0A8M1P9T0, Q6P5L2
      Related
      ENSDARP00000038227.6, ENSDART00000034850.8
      Conserved Domains (1) summary
      cl00221
      Location:2 → 86
      ACBP; Acyl CoA binding protein (ACBP) binds thiol esters of long fatty acids and coenzyme A in a one-to-one binding mode with high specificity and affinity. Acyl-CoAs are important intermediates in fatty lipid synthesis and fatty acid degradation and play a ...

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007120.7 Reference GRCz11 Primary Assembly

      Range
      907459..914886
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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