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    npas4a neuronal PAS domain protein 4a [ Danio rerio (zebrafish) ]

    Gene ID: 724016, updated on 9-Dec-2024

    Summary

    Official Symbol
    npas4aprovided by ZNC
    Official Full Name
    neuronal PAS domain protein 4aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-060616-396
    See related
    Ensembl:ENSDARG00000055752 AllianceGenome:ZFIN:ZDB-GENE-060616-396
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    npas4; wu:fj52d04; zgc:136764
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within blood vessel development and forebrain development. Predicted to be located in nucleus. Is expressed in forebrain. Orthologous to human NPAS4 (neuronal PAS domain protein 4). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

    See npas4a in Genome Data Viewer
    Location:
    chromosome: 14
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 14 NC_007125.7 (30636955..30642819, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 14 NC_007125.6 (30296641..30302505, complement)

    Chromosome 14 - NC_007125.7Genomic Context describing neighboring genes Neighboring gene prefoldin subunit 6 Neighboring gene mitochondrial ribosomal protein L11 Neighboring gene transmembrane protein 265 Neighboring gene uncharacterized LOC108192168 Neighboring gene EGF containing fibulin extracellular matrix protein 2a Neighboring gene fibroblast growth factor (acidic) intracellular binding protein a

    Genomic regions, transcripts, and products

    Expression

    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    General gene information

    Markers

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables DNA-binding transcription factor activity, RNA polymerase II-specific ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein dimerization activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within blood vessel development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in excitatory postsynaptic potential ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within forebrain development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in inhibitory postsynaptic potential ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in inhibitory synapse assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in learning ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in long-term memory ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within nervous system development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of DNA-templated transcription ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of transcription by RNA polymerase II ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of synaptic plasticity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of synaptic transmission, GABAergic ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in short-term memory ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in social behavior ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    neuronal PAS domain-containing protein 4A
    Names
    HLH-PAS transcription factor NXF
    bHLH-PAS type transcription factor NXF
    neuronal PAS domain protein 4
    neuronal PAS domain-containing protein 4
    neuronal PAS4
    neuronal PAS4A

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001045321.1NP_001038786.1  neuronal PAS domain-containing protein 4A

      See identical proteins and their annotated locations for NP_001038786.1

      Status: PROVISIONAL

      Source sequence(s)
      BC117648
      UniProtKB/Swiss-Prot
      Q1ECW2, Q5I7E4
      Related
      ENSDARP00000072616.4, ENSDART00000078154.5
      Conserved Domains (3) summary
      smart00091
      Location:77139
      PAS; PAS domain
      cd00130
      Location:238321
      PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
      pfam14598
      Location:234336
      PAS_11; PAS domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007125.7 Reference GRCz11 Primary Assembly

      Range
      30636955..30642819 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)