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    ncana neurocan a [ Danio rerio (zebrafish) ]

    Gene ID: 407661, updated on 4-Jan-2025

    Summary

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    Official Symbol
    ncanaprovided by ZNC
    Official Full Name
    neurocan aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-051230-1
    See related
    AllianceGenome:ZFIN:ZDB-GENE-051230-1
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    ncan; cspg3; ncanl; cspg3l
    Summary
    Predicted to enable calcium ion binding activity; carbohydrate binding activity; and hyaluronic acid binding activity. Predicted to act upstream of or within cell adhesion. Predicted to be located in extracellular region and plasma membrane. Orthologous to human NCAN (neurocan). [provided by Alliance of Genome Resources, Jan 2025]
    Orthologs
    all
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    Genomic context

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    See ncana in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 2 NC_007113.7 (59478040..59625677)
    105 previous assembly GRCz10 (GCF_000002035.5) 2 NC_007113.6 (59386998..59531927, complement)

    Chromosome 2 - NC_007113.7Genomic Context describing neighboring genes Neighboring gene tripartite motif-containing protein 16-like Neighboring gene uncharacterized LOC110438157 Neighboring gene uncharacterized LOC137488396

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Characterization of dermacan, a novel zebrafish lectican gene, expressed in dermal bones. Kang JS, et al. Mech Dev, 2004 Mar. PMID 15003632
    2. Expression of strawberry notch family genes during zebrafish embryogenesis. Takano A, et al. Dev Dyn, 2010 Jun. PMID 20503374
    3. Phenotypic Landscape of Schizophrenia-Associated Genes Defines Candidates and Their Shared Functions. Thyme SB, et al. Cell, 2019 Apr 4. PMID 30929901, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
    5. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables carbohydrate binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hyaluronic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within cell adhesion IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    neurocan core protein
    Names
    chondroitin sulfate proteoglycan 3, like
    neurocan, like

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007113.7 Reference GRCz11 Primary Assembly

      Range
      59478040..59625677
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_002660981.7 → XP_002661027.3  neurocan core protein isoform X1

      UniProtKB/TrEMBL
      A0A8M1RLN8
      Conserved Domains (9) summary
      cd05902
      Location:45 → 151
      Ig_Neurocan; Immunoglobulin (Ig)-like domain of the chondroitin sulfate proteoglycan core protein (CSPG), neurocan
      cd00033
      Location:1035 → 1091
      CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
      PHA03255
      Location:685 → 802
      PHA03255; BDLF3; Provisional
      smart00410
      Location:47 → 147
      IG_like; Immunoglobulin like
      cd00054
      Location:866 → 902
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      cd03517
      Location:150 → 244
      Link_domain_CSPGs_modules_1_3; Link_domain_CSPGs_modules_1_3; this extracellular link domain is found in the first and third link modules of the chondroitin sulfate proteoglycan core protein (CSPG) aggrecan. In addition, it is found in the first link module of three other CSPGs: ...
      pfam00008
      Location:837 → 861
      EGF; EGF-like domain
      cl02432
      Location:908 → 1031
      CLECT; C-type lectin (CTL)/C-type lectin-like (CTLD) domain
      cl02612
      Location:251 → 342
      Link_Domain; The link domain is a hyaluronan (HA)-binding domain. It functions to mediate adhesive interactions during inflammatory leukocyte homing and tumor metastasis. It is found in the CD44 receptor and in human TSG-6. TSG-6 is the protein product of the tumor ...

    2. XM_068215108.1 → XP_068071209.1  neurocan core protein isoform X2

    Nucleotide Protein Strain
    Heading Accession and Version

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