lrrn1 leucine rich repeat neuronal 1 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: lrrn1provided by ZNC
Official Full Name: leucine rich repeat neuronal 1provided by ZNC
Primary source: ZFIN:ZDB-GENE-071126-1
See related: Ensembl:ENSDARG00000060115 AllianceGenome:ZFIN:ZDB-GENE-071126-1
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Summary: Acts upstream of or within olfactory nerve formation and olfactory placode morphogenesis. Predicted to be located in membrane. Predicted to be active in extracellular matrix and extracellular space. Is expressed in basal plate midbrain region; hindbrain neural keel; nervous system; neural plate; and somite. Orthologous to human LRRN1 (leucine rich repeat neuronal 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 6

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	6	NC_007117.7 (43076516..43092175, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	6	NC_007117.6 (43078980..43094639, complement)

Chromosome 6 - NC_007117.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

fc41b03.x1 (e-PCR)
- UniSTS:188133

fc41b09.x1 (e-PCR)
- UniSTS:193770

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within olfactory nerve formation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within olfactory placode morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in extracellular matrix	IBA Inferred from Biological aspect of Ancestor more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: leucine-rich repeat neuronal protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001130694.1 → NP_001124166.1 leucine-rich repeat neuronal protein 1 precursor

See identical proteins and their annotated locations for NP_001124166.1

Status: PROVISIONAL

Source sequence(s)

BC155656

UniProtKB/TrEMBL

A0A8M1NKY2, A9JRH0

Related

ENSDARP00000078824.3, ENSDART00000084389.5

Conserved Domains (8) summary

smart00060
Location:532 → 601

FN3; Fibronectin type 3 domain

smart00082
Location:372 → 414

LRRCT; Leucine rich repeat C-terminal domain

smart00410
Location:433 → 517

IG_like; Immunoglobulin like

cd00116
Location:86 → 276

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

sd00031
Location:340 → 353

LRR_1; leucine-rich repeat [structural motif]

sd00033
Location:98 → 121

LRR_RI; leucine-rich repeat [structural motif]

pfam13855
Location:97 → 156

LRR_8; Leucine rich repeat

cl11960
Location:441 → 517

Ig; Immunoglobulin domain