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    kank3 KN motif and ankyrin repeat domains 3 [ Danio rerio (zebrafish) ]

    Gene ID: 558407, updated on 9-Dec-2024

    Summary

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    Official Symbol
    kank3provided by ZNC
    Official Full Name
    KN motif and ankyrin repeat domains 3provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-081105-185
    See related
    Ensembl:ENSDARG00000076566 AllianceGenome:ZFIN:ZDB-GENE-081105-185
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    si:dkeyp-104h9.6
    Summary
    Predicted to be involved in negative regulation of actin filament polymerization. Predicted to be active in cytoplasm and cytoskeleton. Is expressed in several structures, including dorsal fin fold; fin bud; gut; neural tube; and vasculature. Orthologous to human KANK3 (KN motif and ankyrin repeat domains 3). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See kank3 in Genome Data Viewer
    Location:
    chromosome: 8
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 8 NC_007119.7 (47755126..47818358, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 8 NC_007119.6 (47769629..47811762, complement)

    Chromosome 8 - NC_007119.7Genomic Context describing neighboring genes Neighboring gene dipeptidyl-peptidase 9 Neighboring gene si:ch211-243p7.3 Neighboring gene si:dkeyp-104h9.5 Neighboring gene NADH:ubiquinone oxidoreductase subunit A7 Neighboring gene Pim proto-oncogene, serine/threonine kinase, related 185 Neighboring gene procollagen-lysine, 2-oxoglutarate 5-dioxygenase 1a

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. NBP, a zebrafish homolog of human Kank3, is a novel Numb interactor essential for epidermal integrity and neurulation. Boggetti B, et al. Dev Biol, 2012 May 1. PMID 22387208
    2. Evolutionary and developmental analysis reveals KANK genes were co-opted for vertebrate vascular development. Hensley MR, et al. Sci Rep, 2016 Jun 13. PMID 27292017, Free PMC Article
    3. 15000 unique zebrafish EST clusters and their future use in microarray for profiling gene expression patterns during embryogenesis. Lo J, et al. Genome Res, 2003 Mar. PMID 12618376, Free PMC Article
    4. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. a possible role of NBP in establishing and maintaining cell adhesion and tissue integrity during gastrulation and later in development
      Title: NBP, a zebrafish homolog of human Kank3, is a novel Numb interactor essential for epidermal integrity and neurulation.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by ZFIN

    Process Evidence Code Pubs
    involved_in negative regulation of actin filament polymerization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within negative regulation of actin filament polymerization IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    KN motif and ankyrin repeat domain-containing protein 3
    Names
    NBP
    Numb-Binding Protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001257149.1 → NP_001244078.1  KN motif and ankyrin repeat domain-containing protein 3

      See identical proteins and their annotated locations for NP_001244078.1

      Status: PROVISIONAL

      Source sequence(s)
      HM151973
      UniProtKB/TrEMBL
      G3CES3
      Related
      ENSDARP00000098697.2, ENSDART00000115050.4
      Conserved Domains (5) summary
      cd00204
      Location:718 → 849
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam12075
      Location:31 → 68
      KN_motif; KN motif
      pfam12796
      Location:728 → 826
      Ank_2; Ankyrin repeats (3 copies)
      pfam13857
      Location:815 → 870
      Ank_5; Ankyrin repeats (many copies)
      sd00045
      Location:723 → 755
      ANK; ANK repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007119.7 Reference GRCz11 Primary Assembly

      Range
      47755126..47818358 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_068222975.1 → XP_068079076.1  KN motif and ankyrin repeat domain-containing protein 3 isoform X1

    Nucleotide Protein
    Heading Accession and Version

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