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    rhoca ras homolog family member Ca [ Danio rerio (zebrafish) ]

    Gene ID: 394125, updated on 15-Dec-2024

    Summary

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    Official Symbol
    rhocaprovided by ZNC
    Official Full Name
    ras homolog family member Caprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040426-1337
    See related
    Ensembl:ENSDARG00000021309 AllianceGenome:ZFIN:ZDB-GENE-040426-1337
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    ARHC; rhoae; zgc:64015
    Summary
    Predicted to enable GTP binding activity; GTPase activity; and protein kinase binding activity. Predicted to be involved in several processes, including actin filament organization; skeletal muscle satellite cell migration; and wound healing, spreading of cells. Predicted to act upstream of or within small GTPase-mediated signal transduction. Predicted to be located in membrane. Predicted to be active in cytosol and plasma membrane. Is expressed in hindbrain; notochord; and rhombomere. Orthologous to human RHOC (ras homolog family member C). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See rhoca in Genome Data Viewer
    Location:
    chromosome: 6
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 6 NC_007117.7 (48382697..48417939, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 6 NC_007117.6 (48383938..48419180, complement)

    Chromosome 6 - NC_007117.7Genomic Context describing neighboring genes Neighboring gene Mov10 RNA helicase a Neighboring gene uncharacterized LOC137496016 Neighboring gene protein phosphatase, Mg2+/Mn2+ dependent, 1J Neighboring gene TAFA chemokine like family member 3a Neighboring gene uncharacterized LOC137496017

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. RhoC maintains vascular homeostasis by regulating VEGF-induced signaling in endothelial cells. Hoeppner LH, et al. J Cell Sci, 2015 Oct 1. PMID 26136364, Free PMC Article
    2. m(6)A modulates haematopoietic stem and progenitor cell specification. Zhang C, et al. Nature, 2017 Sep 14. PMID 28869969
    3. Pax3 loss of function delays tumour progression in kRAS-induced zebrafish rhabdomyosarcoma models. Kahsay A, et al. Sci Rep, 2022 Oct 13. PMID 36229514, Free PMC Article
    4. Genomic annotation and expression analysis of the zebrafish Rho small GTPase family during development and bacterial infection. Salas-Vidal E, et al. Genomics, 2005 Jul. PMID 15894457
    5. Proteolysis regulates cardiomyocyte maturation and tissue integration. Fukuda R, et al. Nat Commun, 2017 Feb 17. PMID 28211472, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Clone Names

    • MGC64015

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables GTP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in actin filament organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell migration IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitotic cytokinesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of actin cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in skeletal muscle satellite cell migration ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within small GTPase-mediated signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in wound healing, spreading of cells ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    ras homolog family member Ca
    Names
    ras homolog gene family, member Ae

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_201150.1 → NP_957444.1  ras homolog family member Ca

      See identical proteins and their annotated locations for NP_957444.1

      Status: PROVISIONAL

      Source sequence(s)
      BC053200
      UniProtKB/TrEMBL
      A0A8M1PIV7, Q7T399
      Related
      ENSDARP00000084961.3, ENSDART00000090528.5
      Conserved Domains (2) summary
      smart00174
      Location:8 → 180
      RHO; Rho (Ras homology) subfamily of Ras-like small GTPases
      cd01870
      Location:5 → 179
      RhoA_like; Ras homology family A (RhoA)-like includes RhoA, RhoB and RhoC

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007117.7 Reference GRCz11 Primary Assembly

      Range
      48382697..48417939 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version

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