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    pkz protein kinase containing Z-DNA binding domains [ Danio rerio (zebrafish) ]

    Gene ID: 503703, updated on 9-Dec-2024

    Summary

    Official Symbol
    pkzprovided by ZNC
    Official Full Name
    protein kinase containing Z-DNA binding domainsprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-050301-2
    See related
    Ensembl:ENSDARG00000052396 AllianceGenome:ZFIN:ZDB-GENE-050301-2
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:136657
    Summary
    Enables left-handed Z-DNA binding activity and protein kinase activity. Predicted to be involved in negative regulation of translation and regulation of translational initiation. Predicted to act upstream of or within protein phosphorylation. Predicted to be active in cytoplasm and nucleus. Is expressed in several structures, including digestive system; eye; heart; musculature system; and pleuroperitoneal region. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

    See pkz in Genome Data Viewer
    Location:
    chromosome: 13
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 13 NC_007124.7 (50189890..50200154, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 13 NC_007124.6 (49876647..49886979, complement)

    Chromosome 13 - NC_007124.7Genomic Context describing neighboring genes Neighboring gene lysosomal trafficking regulator Neighboring gene nidogen 1a Neighboring gene G protein-coupled receptor 137Ba Neighboring gene eukaryotic translation initiation factor 2-alpha kinase 2 Neighboring gene G patch domain containing 11

    Genomic regions, transcripts, and products

    Expression

    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    General gene information

    Clone Names

    • MGC136657, MGC158143

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables double-stranded RNA adenosine deaminase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables eukaryotic translation initiation factor 2alpha kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables left-handed Z-DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in negative regulation of translation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of translational initiation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    protein kinase containing Z-DNA binding domains

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001040376.2NP_001035466.1  protein kinase containing Z-DNA binding domains

      See identical proteins and their annotated locations for NP_001035466.1

      Status: PROVISIONAL

      Source sequence(s)
      BC131857
      UniProtKB/TrEMBL
      A2RRU6, F6NJL1, Q5NE12, Q5NE14
      Related
      ENSDARP00000033668.5, ENSDART00000038391.8
      Conserved Domains (3) summary
      smart00220
      Location:170491
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cl02659
      Location:470
      z-alpha; Adenosine deaminase z-alpha domain
      cl21453
      Location:163495
      PKc_like; Protein Kinases, catalytic domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007124.7 Reference GRCz11 Primary Assembly

      Range
      50189890..50200154 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_068212839.1XP_068068940.1  protein kinase containing Z-DNA binding domains isoform X1

      UniProtKB/TrEMBL
      Q5NE12