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    erbin erbb2 interacting protein [ Danio rerio (zebrafish) ]

    Gene ID: 566811, updated on 9-Dec-2024

    Summary

    Official Symbol
    erbinprovided by ZNC
    Official Full Name
    erbb2 interacting proteinprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-061103-403
    See related
    Ensembl:ENSDARG00000044281 AllianceGenome:ZFIN:ZDB-GENE-061103-403
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    erbb2ip; zgc:152984
    Summary
    Predicted to enable protein kinase binding activity. Predicted to be involved in several processes, including establishment or maintenance of epithelial cell apical/basal polarity; protein localization to postsynapse; and receptor clustering. Predicted to be active in adherens junction; basolateral plasma membrane; and postsynaptic density. Predicted to colocalize with postsynaptic membrane. Is expressed in intestine. Orthologous to human ERBIN (erbb2 interacting protein). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

    See erbin in Genome Data Viewer
    Location:
    chromosome: 10
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 10 NC_007121.7 (15454856..15599149)
    105 previous assembly GRCz10 (GCF_000002035.5) 10 NC_007121.6 (15496737..15641030)

    Chromosome 10 - NC_007121.7Genomic Context describing neighboring genes Neighboring gene trafficking protein particle complex subunit 13 Neighboring gene small glutamine rich tetratricopeptide repeat co-chaperone beta Neighboring gene neurolysin (metallopeptidase M3 family) Neighboring gene zinc finger, AN1-type domain 5b Neighboring gene structural maintenance of chromosomes 5

    Genomic regions, transcripts, and products

    Expression

    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Pathways from PubChem

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001193543.1NP_001180472.1  erbin

      Status: VALIDATED

      Source sequence(s)
      BX640501, CR854840, CR925725
      UniProtKB/TrEMBL
      A0A0R4IEU0, A0A8M1NUM6
      Related
      ENSDARP00000133788.1, ENSDART00000163446.2
      Conserved Domains (5) summary
      cd00116
      Location:8267
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      cd00992
      Location:12691325
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      sd00033
      Location:2447
      LRR_RI; leucine-rich repeat [structural motif]
      pfam07223
      Location:9511142
      DUF1421; Protein of unknown function (DUF1421)
      pfam13855
      Location:230288
      LRR_8; Leucine rich repeat

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007121.7 Reference GRCz11 Primary Assembly

      Range
      15454856..15599149
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005155576.5XP_005155633.1  erbin isoform X1

      UniProtKB/TrEMBL
      A0A8M2B233
      Conserved Domains (5) summary
      cd00116
      Location:8267
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      cd00992
      Location:13311387
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      sd00033
      Location:2447
      LRR_RI; leucine-rich repeat [structural motif]
      pfam07223
      Location:9611152
      DUF1421; Protein of unknown function (DUF1421)
      pfam13855
      Location:230288
      LRR_8; Leucine rich repeat
    2. XM_005155578.5XP_005155635.1  erbin isoform X3

      UniProtKB/TrEMBL
      A0A8M2B2B1
      Conserved Domains (5) summary
      COG4886
      Location:33418
      LRR; Leucine-rich repeat (LRR) protein [Transcription]
      cd00116
      Location:8267
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      cd00992
      Location:12981354
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      sd00033
      Location:2447
      LRR_RI; leucine-rich repeat [structural motif]
      pfam07223
      Location:9611152
      DUF1421; Protein of unknown function (DUF1421)
    3. XM_005155577.4XP_005155634.1  erbin isoform X2

      UniProtKB/TrEMBL
      A0A8M2B2G8, E7EYJ7
      Related
      ENSDARP00000104608.2, ENSDART00000129441.4
      Conserved Domains (5) summary
      cd00116
      Location:8267
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      cd00992
      Location:13211377
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      sd00033
      Location:2447
      LRR_RI; leucine-rich repeat [structural motif]
      pfam07223
      Location:9511142
      DUF1421; Protein of unknown function (DUF1421)
      pfam13855
      Location:230288
      LRR_8; Leucine rich repeat
    4. XM_068223813.1XP_068079914.1  erbin isoform X4

      Related
      ENSDARP00000106706.2, ENSDART00000123935.4
    5. XM_068223814.1XP_068079915.1  erbin isoform X5

      Related
      ENSDARP00000153721.1, ENSDART00000193752.1

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001080031.1: Suppressed sequence

      Description
      NM_001080031.1: This RefSeq was suppressed temporarily based on the calculation that the encoded protein was shorter than proteins from the putative ortholog from human: ERBB2IP (GeneID:55914).