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    ppp6r2a protein phosphatase 6, regulatory subunit 2a [ Danio rerio (zebrafish) ]

    Gene ID: 560729, updated on 4-Jan-2025

    Summary

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    Official Symbol
    ppp6r2aprovided by ZNC
    Official Full Name
    protein phosphatase 6, regulatory subunit 2aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-5428
    See related
    Ensembl:ENSDARG00000045540 AllianceGenome:ZFIN:ZDB-GENE-030131-5428
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    saps2; ppp6r2; fd18a05; wu:fd18a05; zgc:136621; si:dkey-159a18.3
    Summary
    Predicted to enable protein phosphatase regulator activity. Predicted to be involved in regulation of signal transduction. Predicted to be active in cytosol and nucleus. Orthologous to human PPP6R2 (protein phosphatase 6 regulatory subunit 2). [provided by Alliance of Genome Resources, Jan 2025]
    Orthologs
    all
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    Genomic context

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    See ppp6r2a in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 4 NC_007115.7 (20082475..20101740)
    105 previous assembly GRCz10 (GCF_000002035.5) 4 NC_007115.6 (20093499..20109782)

    Chromosome 4 - NC_007115.7Genomic Context describing neighboring genes Neighboring gene GRIP and coiled-coil domain containing 1 Neighboring gene DENN/MADD domain containing 6B Neighboring gene si:dkey-159a18.1 Neighboring gene coiled-coil domain containing 146 Neighboring gene FAM3 metabolism regulating signaling molecule C

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Hematopoietic gene expression profile in zebrafish kidney marrow. Song HD, et al. Proc Natl Acad Sci U S A, 2004 Nov 16. PMID 15520368, Free PMC Article
    2. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
    3. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC136621

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables protein phosphatase binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein phosphatase regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    serine/threonine-protein phosphatase 6 regulatory subunit 2a
    Names
    SAPS domain family, member 2
    protein phosphatase 6, regulatory subunit 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001025509.1 → NP_001020680.1  serine/threonine-protein phosphatase 6 regulatory subunit 2a

      See identical proteins and their annotated locations for NP_001020680.1

      Status: PROVISIONAL

      Source sequence(s)
      BX890616
      UniProtKB/TrEMBL
      Q1RM06, Q5RGI5
      Related
      ENSDARP00000066960.5, ENSDART00000066961.6
      Conserved Domains (2) summary
      pfam03157
      Location:697 → 820
      Glutenin_hmw; High molecular weight glutenin subunit
      pfam04499
      Location:128 → 537
      SAPS; SIT4 phosphatase-associated protein

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007115.7 Reference GRCz11 Primary Assembly

      Range
      20082475..20101740
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021475043.2 → XP_021330718.1  serine/threonine-protein phosphatase 6 regulatory subunit 2a isoform X1

      UniProtKB/TrEMBL
      Q1RM06, Q5RGI5
      Related
      ENSDARP00000152642.1, ENSDART00000188635.1
      Conserved Domains (2) summary
      pfam03157
      Location:697 → 820
      Glutenin_hmw; High molecular weight glutenin subunit
      pfam04499
      Location:128 → 537
      SAPS; SIT4 phosphatase-associated protein
    Nucleotide Protein Strain
    Heading Accession and Version

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