lfng LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: lfngprovided by ZNC
Official Full Name: LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferaseprovided by ZNC
Primary source: ZFIN:ZDB-GENE-980605-16
See related: Ensembl:ENSDARG00000037879 AllianceGenome:ZFIN:ZDB-GENE-980605-16
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: l-fng; id:ibd2614; id:ibd5029; id:ibd5138; wu:fc69h02; wu:fi34c01
Summary: Predicted to enable O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity. Acts upstream of or within fin regeneration; hypochord development; and negative regulation of neuron differentiation. Predicted to be located in Golgi membrane. Is expressed in several structures, including blastodisc; central nervous system; germ ring; neural plate; and sensory system. Human ortholog(s) of this gene implicated in spondylocostal dysostosis 3. Orthologous to human LFNG (LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 3

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	3	NC_007114.7 (41917496..41926869)
105	previous assembly	GRCz10 (GCF_000002035.5)	3	NC_007114.6 (41775639..41785011)

Chromosome 3 - NC_007114.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Lfng acts in a feedback loop downstream of proneural genes.
Title: Lunatic fringe promotes the lateral inhibition of neurogenesis.
The sequence and embryonic expression of lfng were studied.
Title: Sequence and embryonic expression of three zebrafish fringe genes: lunatic fringe, radical fringe, and manic fringe.
lfng regulates delta-notch induction of hypochord.
Title: lunatic fringe regulates Delta-Notch induction of hypochord in zebrafish.

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity	IEA Inferred from Electronic Annotation more info
enables glycosyltransferase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within Notch signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cell differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within fin regeneration	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within hypochord development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of neuron differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within nervous system development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within pattern specification process	IEA Inferred from Electronic Annotation more info
involved_in regulation of Notch signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of Notch signaling pathway	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
located_in Golgi membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: beta-1,3-N-acetylglucosaminyltransferase lunatic fringe

Names: O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase; lunatic fringe homolog

NP_571046.1

EC 2.4.1.222

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.