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    nppc natriuretic peptide C [ Danio rerio (zebrafish) ]

    Gene ID: 570244, updated on 9-Dec-2024

    Summary

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    Official Symbol
    nppcprovided by ZNC
    Official Full Name
    natriuretic peptide Cprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-070705-24
    See related
    Ensembl:ENSDARG00000068126 AllianceGenome:ZFIN:ZDB-GENE-070705-24
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    cnp4; si:ch211-126j24.3
    Summary
    Predicted to enable hormone activity and hormone receptor binding activity. Predicted to be involved in cGMP biosynthetic process and receptor guanylyl cyclase signaling pathway. Predicted to act upstream of or within blood vessel diameter maintenance. Predicted to be located in extracellular region. Is expressed in medulla oblongata; oocyte; oocyte stage V; ovarian follicle; and preoptic area. Human ortholog(s) of this gene implicated in depressive disorder and hypertension. Orthologous to human NPPC (natriuretic peptide C). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See nppc in Genome Data Viewer
    Location:
    chromosome: 22
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 22 NC_007133.7 (38614887..38621438, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 22 NC_007133.6 (38628601..38635152, complement)

    Chromosome 22 - NC_007133.7Genomic Context describing neighboring genes Neighboring gene si:ch211-126j24.1 Neighboring gene kinesin light chain 4 Neighboring gene uncharacterized LOC137488978 Neighboring gene alkaline phosphatase, intestinal, tandem duplicate 1 Neighboring gene alkaline phosphatase, intestinal, tandem duplicate 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Role of natriuretic peptide receptor 2-mediated signaling in meiotic arrest of zebrafish oocytes and its estrogen regulation through G protein-coupled estrogen receptor (Gper). Pang Y, et al. Gen Comp Endocrinol, 2018 Sep 1. PMID 29574150
    2. Pharmacological and Genetic Disruption of C-Type Natriuretic Peptide (nppcl) Expression in Zebrafish (Danio rerio) Causes Stunted Growth during Development. Lessey AJ, et al. Int J Mol Sci, 2023 Aug 18. PMID 37629102, Free PMC Article
    3. Origin and function of activated fibroblast states during zebrafish heart regeneration. Hu B, et al. Nat Genet, 2022 Aug. PMID 35864193, Free PMC Article
    4. Single-cell chromatin profiling reveals genetic programs activating proregenerative states in nonmyocyte cells. Dong Y, et al. Sci Adv, 2024 Feb 23. PMID 38381829, Free PMC Article
    5. Gene duplication of C-type natriuretic peptide-4 (CNP4) in teleost lineage elicits subfunctionalization of ancestral CNP. Katayama Y, et al. Cell Tissue Res, 2022 May. PMID 35171324

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables hormone activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables hormone activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hormone receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within blood vessel diameter maintenance IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cGMP biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in receptor guanylyl cyclase signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    C-type natriuretic peptide
    Names
    C-type natriuretic peptide-like

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001109940.1 → NP_001103410.1  C-type natriuretic peptide precursor

      Status: PROVISIONAL

      Source sequence(s)
      BX088728
      UniProtKB/TrEMBL
      A0A8M1NEI0, A8E7F8
      Related
      ENSDARP00000089102.4, ENSDART00000098330.5
      Conserved Domains (1) summary
      pfam00212
      Location:86 → 119
      ANP; Atrial natriuretic peptide

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007133.7 Reference GRCz11 Primary Assembly

      Range
      38614887..38621438 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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