cpap centrosome assembly and centriole elongation protein [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: cpapprovided by ZNC
Official Full Name: centrosome assembly and centriole elongation proteinprovided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-6323
See related: Ensembl:ENSDARG00000018121 AllianceGenome:ZFIN:ZDB-GENE-030131-6323
Gene type: protein coding
RefSeq status: MODEL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: cenpj; wu:fi46g11; si:dkey-46k9.9
Summary: Enables protein domain specific binding activity. Predicted to be involved in centriole elongation and cilium assembly. Predicted to be active in centriole and centrosome. Human ortholog(s) of this gene implicated in Seckel syndrome 4; primary autosomal recessive microcephaly; and primary autosomal recessive microcephaly 6. Orthologous to human CENPJ (centromere protein J). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 9

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	9	NC_007120.7 (29571812..29579898, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	9	NC_007120.6 (29761023..29769162, complement)

Chromosome 9 - NC_007120.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data suggest that the single G-box domain (that appears to fold into 14-20 antiparallel beta-strands) of cenpj has stable but dynamic structure; CRAP forms multimers (in solution and in crystals) of elongated fibrils similar to amyloid fibrils. [REVIEW]
Title: The centriolar protein CPAP G-box: an amyloid fibril in a single domain.
CPAP acts as a horizontal "strut" that joins the centriolar scaffold with microtubules, whereas G-box domains form perpendicular connections.
Title: Structural analysis of the G-box domain of the microcephaly protein CPAP suggests a role in centriole architecture.

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General gene information

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Markers

ha3057 (e-PCR)
- UniSTS:515633

fi46g11.x1 (e-PCR)
- UniSTS:197586

fd09b03.y1 (e-PCR)
- UniSTS:195060

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein domain specific binding	IDA Inferred from Direct Assay more info	PubMed
enables tubulin binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in centriole elongation	IBA Inferred from Biological aspect of Ancestor more info
involved_in cilium assembly	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in centriole	IBA Inferred from Biological aspect of Ancestor more info
is_active_in centrosome	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: centromere protein J

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007120.7 Reference GRCz11 Primary Assembly

Range

29571812..29579898 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_068223639.1 → XP_068079740.1 centromere protein J

UniProtKB/TrEMBL

A0A8M9QBF6, E7FCY1
XM_021478969.2 → XP_021334644.1 centromere protein J

UniProtKB/TrEMBL

A0A8M9QBF6, E7FCY1

Related

ENSDARP00000117414.1, ENSDART00000140876.2

Conserved Domains (3) summary

pfam07202
Location:947 → 1121

Tcp10_C; T-complex protein 10 C-terminus

pfam09726
Location:512 → 820

Macoilin; Transmembrane protein

cl25732
Location:668 → 823

SMC_N; RecF/RecN/SMC N terminal domain

Reference GRCz11 ALT_DRER_TU_1

Genomic

NW_018394759.1 Reference GRCz11 ALT_DRER_TU_1

Range

176927..185013 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_068218556.1 → XP_068074657.1 centromere protein J

UniProtKB/TrEMBL

A0A8M9QBF6, E7FCY1
XM_692317.7 → XP_697409.4 centromere protein J

See identical proteins and their annotated locations for XP_697409.4

UniProtKB/TrEMBL

A0A8M9QBF6, E7FCY1

Conserved Domains (3) summary

pfam07202
Location:947 → 1121

Tcp10_C; T-complex protein 10 C-terminus

pfam09726
Location:512 → 820

Macoilin; Transmembrane protein

cl25732
Location:668 → 823

SMC_N; RecF/RecN/SMC N terminal domain