lzts2a leucine zipper, putative tumor suppressor 2a [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: lzts2aprovided by ZNC
Official Full Name: leucine zipper, putative tumor suppressor 2aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-090313-276
See related: Ensembl:ENSDARG00000074597 AllianceGenome:ZFIN:ZDB-GENE-090313-276
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: lzts2; si:dkey-250a11.1
Summary: Enables beta-catenin binding activity. Acts upstream of or within several processes, including cell migration involved in gastrulation; convergent extension; and regulation of signal transduction. Predicted to be located in cytoplasm; microtubule cytoskeleton; and midbody. Is expressed in several structures, including digestive system; nervous system; otic vesicle; pectoral fin bud; and tail bud. Orthologous to human LZTS2 (leucine zipper tumor suppressor 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 13

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	13	NC_007124.7 (18800403..18943950, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	13	NC_007124.6 (18668939..18814016, complement)

Chromosome 13 - NC_007124.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Lzts2 regulates gastrula CE movements, dorsoventral patterning, and midline convergence and specification of organ precursors through interaction with and the export of nuclear beta-catenins in zebrafish.
Title: Lzts2 regulates embryonic cell movements and dorsoventral patterning through interaction with and export of nuclear β-catenin in zebrafish.

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables beta-catenin binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within Wnt signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cell division	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cell migration involved in gastrulation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within cell migration involved in gastrulation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within convergent extension	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within convergent extension	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within convergent extension	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within dorsal/ventral pattern formation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within dorsal/ventral pattern formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in microtubule severing	IEA Inferred from Electronic Annotation more info
involved_in mitotic cytokinesis	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of canonical Wnt signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within negative regulation of canonical Wnt signaling pathway	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of canonical Wnt signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nuclear export	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of BMP signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in spindle midzone assembly	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in centrosome	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in microtubule	IEA Inferred from Electronic Annotation more info
located_in midbody	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: leucine zipper putative tumor suppressor 2a

Names: leucine zipper, putative tumor suppressor 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001145606.1 → NP_001139078.1 leucine zipper putative tumor suppressor 2a

Status: PROVISIONAL

Source sequence(s)

BX936291

UniProtKB/TrEMBL

A0A8M1NQ64, B8A6E8, F1QX90

Related

ENSDARP00000122442.1, ENSDART00000146795.3

Conserved Domains (1) summary

pfam06818
Location:479 → 709

Fez1; Fez1