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    itfg2 integrin alpha FG-GAP repeat containing 2 [ Danio rerio (zebrafish) ]

    Gene ID: 550607, updated on 4-Jan-2025

    Summary

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    Official Symbol
    itfg2provided by ZNC
    Official Full Name
    integrin alpha FG-GAP repeat containing 2provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-041008-161
    See related
    Ensembl:ENSDARG00000002174 AllianceGenome:ZFIN:ZDB-GENE-041008-161
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    im:7138587; zgc:110581; si:dkey-264k15.2
    Summary
    Predicted to be involved in regulation of TOR signaling. Predicted to act upstream of or within integrin-mediated signaling pathway. Predicted to be part of KICSTOR complex. Orthologous to human ITFG2 (integrin alpha FG-GAP repeat containing 2). [provided by Alliance of Genome Resources, Jan 2025]
    Orthologs
    human mouse all
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    Genomic context

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    See itfg2 in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 4 NC_007115.7 (17539095..17553996)
    105 previous assembly GRCz10 (GCF_000002035.5) 4 NC_007115.6 (17550119..17565020)

    Chromosome 4 - NC_007115.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101884203 Neighboring gene RecQ helicase-like Neighboring gene nuclear receptor interacting protein 2 Neighboring gene kelch-like family, member 42 Neighboring gene CWF19 like cell cycle control factor 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Regulation of spermatogonial development by Fsh: The complementary roles of locally produced Igf and Wnt signaling molecules in adult zebrafish testis. Safian D, et al. Gen Comp Endocrinol, 2019 Dec 1. PMID 31415728
    2. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
    5. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within integrin-mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of TOR signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of KICSTOR complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    KICSTOR complex protein ITFG2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001017908.2 → NP_001017908.2  KICSTOR complex protein ITFG2

      See identical proteins and their annotated locations for NP_001017908.2

      Status: VALIDATED

      Source sequence(s)
      BX914215
      UniProtKB/TrEMBL
      A0A8M1N5U8, Q5RHI2
      Related
      ENSDARP00000020383.5, ENSDART00000013313.6
      Conserved Domains (2) summary
      pfam15907
      Location:49 → 383
      Itfg2; Integrin-alpha FG-GAP repeat-containing protein 2
      cl24051
      Location:21 → 52
      BBS2_Mid; Ciliary BBSome complex subunit 2, middle region

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007115.7 Reference GRCz11 Primary Assembly

      Range
      17539095..17553996
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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