axin1 axin 1 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: axin1provided by ZNC
Official Full Name: axin 1provided by ZNC
Primary source: ZFIN:ZDB-GENE-000403-1
See related: Ensembl:ENSDARG00000102964 AllianceGenome:ZFIN:ZDB-GENE-000403-1
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: wu:fi22e03; wu:fj14c08; wu:fk11b03; zgc:109872
Summary: Predicted to enable several functions, including I-SMAD binding activity; beta-catenin binding activity; and enzyme binding activity. Involved in anterior/posterior pattern specification and regulation of signal transduction. Acts upstream of or within several processes, including embryonic morphogenesis; regionalization; and regulation of MAPK cascade. Part of beta-catenin destruction complex. Is expressed in forebrain; habenula; head; midbrain; and vertebral column. Human ortholog(s) of this gene implicated in hepatocellular carcinoma; lung cancer; and urinary bladder cancer. Orthologous to human AXIN1 (axin 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 3

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	3	NC_007114.7 (43579490..43687314, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	3	NC_007114.6 (42878573..42984730, complement)

Chromosome 3 - NC_007114.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

beta-catenin1 cannot revert the ich phenotype because it may be under the control of a GSK3beta-independent mechanism that required Axin's RGS domain function.
Title: The increase in maternal expression of axin1 and axin2 contribute to the zebrafish mutant ichabod ventralized phenotype.
analysis of differential role of Axin RGS domain function in Wnt signaling during anteroposterior patterning and maternal axis formation
Title: Differential role of Axin RGS domain function in Wnt signaling during anteroposterior patterning and maternal axis formation.
Dab2 stabilizes Axin and attenuates Wnt/beta-catenin signaling by preventing PP1 from binding Axin
Title: Dab2 stabilizes Axin and attenuates Wnt/beta-catenin signaling by preventing protein phosphatase 1 (PP1)-Axin interactions.
Overactivation of Wnt/Axin1/beta-catenin signaling during late gastrulation leads to bilateral epithalamic expression of Nodal pathway genes independently of lateral plate mesoderm Nodal signaling.
Title: Wnt/Axin1/beta-catenin signaling regulates asymmetric nodal activation, elaboration, and concordance of CNS asymmetries.
A dorsalization pathway that is exerted by Axin/JNK signaling and its inhibitor Aida during vertebrate embryogenesis, is defined.
Title: A beta-catenin-independent dorsalization pathway activated by Axin/JNK signaling and antagonized by aida.
Wnt/Axin/beta-catenin pathway has a role in ventral CNS development
Title: Inhibition of Wnt/Axin/beta-catenin pathway activity promotes ventral CNS midline tissue to adopt hypothalamic rather than floorplate identity.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

fk11b03.x1 (e-PCR)
- UniSTS:200583

fi22e03.x1 (e-PCR)
- UniSTS:197044

fi22e11.y1 (e-PCR)
- UniSTS:197045

fj14c08.y1 (e-PCR)
- UniSTS:198593

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables I-SMAD binding	IBA Inferred from Biological aspect of Ancestor more info
enables beta-catenin binding	IBA Inferred from Biological aspect of Ancestor more info
enables identical protein binding	IBA Inferred from Biological aspect of Ancestor more info
enables molecular adaptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables molecular_function	ND No biological Data available more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein homodimerization activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein kinase binding	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin protein ligase binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within Wnt signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within Wnt signaling pathway involved in somitogenesis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in cell development	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within determination of left/right symmetry	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within dorsal/ventral axis specification	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within dorsal/ventral pattern formation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within dorsal/ventral pattern formation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within embryonic eye morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within eye development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within eye development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within fin regeneration	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within forebrain anterior/posterior pattern specification	IMP Inferred from Mutant Phenotype more info
acts_upstream_of_or_within forebrain development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within forebrain neuron fate commitment	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within lens placode formation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within muscle cell development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within negative regulation of Wnt signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of canonical Wnt signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of canonical Wnt signaling pathway	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of canonical Wnt signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of canonical Wnt signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of canonical Wnt signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within negative regulation of canonical Wnt signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of canonical Wnt signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within neural plate anterior/posterior regionalization	IMP Inferred from Mutant Phenotype more info
involved_in neural plate anterior/posterior regionalization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neural plate pattern specification	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within olfactory placode formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of JNK cascade	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of JUN kinase activity	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of JNK cascade	IDA Inferred from Direct Assay more info	PubMed
involved_in somitogenesis	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
part_of beta-catenin destruction complex	IBA Inferred from Biological aspect of Ancestor more info
part_of beta-catenin destruction complex	IDA Inferred from Direct Assay more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: axin-1

Names: axis inhibition protein 1; masterblind; mbl

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_131503.2 → NP_571578.2 axin-1

See identical proteins and their annotated locations for NP_571578.2

Status: PROVISIONAL

Source sequence(s)

BC099991

UniProtKB/Swiss-Prot

P57094, Q499B7

Related

ENSDARP00000135613.1, ENSDART00000161127.2

Conserved Domains (5) summary

cd08707
Location:93 → 212

RGS_Axin; Regulator of G protein signaling (RGS) domain found in the Axin protein

cd11582
Location:15 → 84

Axin_TNKS_binding; Tankyrase binding N-terminal segment of axin

pfam00778
Location:755 → 830

DIX; DIX domain

pfam08833
Location:469 → 504

Axin_b-cat_bind; Axin beta-catenin binding domain

cl01112
Location:368 → 427

DUF507; Protein of unknown function (DUF507)

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007114.7 Reference GRCz11 Primary Assembly

Range

43579490..43687314 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_021471209.2 → XP_021326884.1 axin-1 isoform X1

UniProtKB/TrEMBL

A0A8M3AY92

Conserved Domains (5) summary

cd08707
Location:93 → 212

RGS_Axin; Regulator of G protein signaling (RGS) domain found in the Axin protein

cd11582
Location:15 → 84

Axin_TNKS_binding; Tankyrase binding N-terminal segment of axin

pfam00778
Location:791 → 866

DIX; DIX domain

pfam08833
Location:469 → 504

Axin_b-cat_bind; Axin beta-catenin binding domain

cl01112
Location:368 → 427

DUF507; Protein of unknown function (DUF507)
XM_021471207.2 → XP_021326882.1 axin-1 isoform X1

UniProtKB/TrEMBL

A0A8M3AY92

Conserved Domains (5) summary

cd08707
Location:93 → 212

RGS_Axin; Regulator of G protein signaling (RGS) domain found in the Axin protein

cd11582
Location:15 → 84

Axin_TNKS_binding; Tankyrase binding N-terminal segment of axin

pfam00778
Location:791 → 866

DIX; DIX domain

pfam08833
Location:469 → 504

Axin_b-cat_bind; Axin beta-catenin binding domain

cl01112
Location:368 → 427

DUF507; Protein of unknown function (DUF507)
XM_017354585.3 → XP_017210074.1 axin-1 isoform X1

UniProtKB/TrEMBL

A0A8M3AY92

Conserved Domains (5) summary

cd08707
Location:93 → 212

RGS_Axin; Regulator of G protein signaling (RGS) domain found in the Axin protein

cd11582
Location:15 → 84

Axin_TNKS_binding; Tankyrase binding N-terminal segment of axin

pfam00778
Location:791 → 866

DIX; DIX domain

pfam08833
Location:469 → 504

Axin_b-cat_bind; Axin beta-catenin binding domain

cl01112
Location:368 → 427

DUF507; Protein of unknown function (DUF507)
XM_009299708.4 → XP_009297983.1 axin-1 isoform X1

UniProtKB/TrEMBL

A0A8M3AY92

Conserved Domains (5) summary

cd08707
Location:93 → 212

RGS_Axin; Regulator of G protein signaling (RGS) domain found in the Axin protein

cd11582
Location:15 → 84

Axin_TNKS_binding; Tankyrase binding N-terminal segment of axin

pfam00778
Location:791 → 866

DIX; DIX domain

pfam08833
Location:469 → 504

Axin_b-cat_bind; Axin beta-catenin binding domain

cl01112
Location:368 → 427

DUF507; Protein of unknown function (DUF507)
XM_068217520.1 → XP_068073621.1 axin-1 isoform X2
XM_017354584.3 → XP_017210073.1 axin-1 isoform X1

UniProtKB/TrEMBL

A0A8M3AY92

Conserved Domains (5) summary

cd08707
Location:93 → 212

RGS_Axin; Regulator of G protein signaling (RGS) domain found in the Axin protein

cd11582
Location:15 → 84

Axin_TNKS_binding; Tankyrase binding N-terminal segment of axin

pfam00778
Location:791 → 866

DIX; DIX domain

pfam08833
Location:469 → 504

Axin_b-cat_bind; Axin beta-catenin binding domain

cl01112
Location:368 → 427

DUF507; Protein of unknown function (DUF507)