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    cremb cAMP responsive element modulator b [ Danio rerio (zebrafish) ]

    Gene ID: 550357, updated on 9-Dec-2024

    Summary

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    Official Symbol
    crembprovided by ZNC
    Official Full Name
    cAMP responsive element modulator bprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-050417-150
    See related
    Ensembl:ENSDARG00000102899 AllianceGenome:ZFIN:ZDB-GENE-050417-150
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:112054
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to act upstream of or within regulation of DNA-templated transcription. Predicted to be located in nucleus. Predicted to be part of ATF4-CREB1 transcription factor complex. Is expressed in retinal ganglion cell layer and spinal cord. Orthologous to human CREM (cAMP responsive element modulator). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See cremb in Genome Data Viewer
    Location:
    chromosome: 24
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 24 NC_007135.7 (31350294..31368520)
    105 previous assembly GRCz10 (GCF_000002035.5) 24 NC_007135.6 (31424151..31431309)

    Chromosome 24 - NC_007135.7Genomic Context describing neighboring genes Neighboring gene ATP-binding cassette, sub-family D (ALD), member 3a Neighboring gene family with sequence similarity 168 member B Neighboring gene copine III Neighboring gene cyclic nucleotide gated channel subunit beta 3, tandem duplicate 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Gene expression analysis of zebrafish retinal ganglion cells during optic nerve regeneration identifies KLF6a and KLF7a as important regulators of axon regeneration. Veldman MB, et al. Dev Biol, 2007 Dec 15. PMID 17949705
    2. Genome wide expression profiling during spinal cord regeneration identifies comprehensive cellular responses in zebrafish. Hui SP, et al. PLoS One, 2014. PMID 24465396, Free PMC Article
    3. Transcriptomic analyses reveal novel genes with sexually dimorphic expression in the zebrafish gonad and brain. Sreenivasan R, et al. PLoS One, 2008 Mar 12. PMID 18335061, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    cAMP responsive element modulator b

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001017664.3 → NP_001017664.1  cAMP responsive element modulator b

      See identical proteins and their annotated locations for NP_001017664.1

      Status: VALIDATED

      Source sequence(s)
      BX682238
      UniProtKB/TrEMBL
      A0A8M1N551, Q567H4
      Related
      ENSDARP00000139282.1, ENSDART00000162668.2
      Conserved Domains (1) summary
      cd14690
      Location:52 → 104
      bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007135.7 Reference GRCz11 Primary Assembly

      Range
      31350294..31368520
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_068217068.1 → XP_068073169.1  cAMP responsive element modulator b isoform X4

    2. XM_021470165.2 → XP_021325840.1  cAMP responsive element modulator b isoform X2

      UniProtKB/TrEMBL
      A0A8M9PXG8
      Conserved Domains (2) summary
      cd14690
      Location:338 → 390
      bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
      pfam02994
      Location:7 → 244
      Transposase_22; L1 transposable element

    3. XM_021470164.2 → XP_021325839.1  cAMP responsive element modulator b isoform X1

      UniProtKB/TrEMBL
      A0A8M9PLS1
      Conserved Domains (2) summary
      cd14690
      Location:338 → 390
      bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
      pfam02994
      Location:7 → 244
      Transposase_22; L1 transposable element

    4. XM_021470166.2 → XP_021325841.1  cAMP responsive element modulator b isoform X3

      UniProtKB/TrEMBL
      A0A8M9PU22
      Conserved Domains (2) summary
      cd14690
      Location:289 → 341
      bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
      pfam02994
      Location:7 → 244
      Transposase_22; L1 transposable element

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018395182.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      184391..191504
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCz11 ALT_DRER_TU_2

    Genomic

    1. NW_018395367.1 Reference GRCz11 ALT_DRER_TU_2

      Range
      189527..196652
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version

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